Lung function measurements in children - copsac

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486 Figure 1: Flow chart Total twins 12.349 twin pairs Born 1/1-1994 – 31/12-2003 RSV number of cases (n) 1.417 729 found in both DNPR and the RSV database 443 registered in DNPR 245 registered in the RSV database Monozygotic cases (n) 165 Dizygotic cases (n) 916 Unknown zygosity cases (n) 336 Concordant cases (n) 108 Discordant cases (n) 57 9 cases (death or no adress information) Names and ID-no. 48 monozygotic discordant cases 5 cases were excluded 43 cases and their twin siblings were invited 5 cases refused 1 case did not respond 487 37 monozygotic discordant cases and their twin siblings were included 20
488 489 Table 1: Comparison of clinical endpoints at follow-up between monozygotic twin pairs discordant for hospitalization for severe respiratory syncytial virus bronchiolitis. Hospitalized vs. not-hospitalized P-value Asthma OR (95% CI) 1.21 (0.36-4.00) 1.00 a History of atopic dermatitis OR (95% CI) 1.14 (0.41-3.14) 1.00 a Use of inhalation steroid ever OR (95% CI) 1.26 (0.49-3.22) 0.81 a Use of beta2-agonist ever OR (95% CI) 1.38 (0.55-3.46) 0.64 a logF E NO (n = 30) Pbb mean (SD) 2.05 (0.66) 2.17 (0.69) 0.16 b logBaseline FEV 1 (n = 25) L mean (SD) 0.42 (0.26) 0.46 (0.23) 0.12 b logMethacholine PD20 (n =24) mol mean (SD) 0.74 (1.83) 0.41 (1.71) 0.27 b logsRaw baseline (n = 12) kPa*s mean (SD) 0.18 (0.26) 0.19 (0.30) 0.79 b sRaw after dry air hyperventilation (n = 5) % increase (median) 27% 18% 0.40 c Positive skin prick test OR (95% CI) 0.36 (0.07-2.08) 0.43 a 490 491 492 493 494 495 496 497 498 499 500 501 502 503 504 Abbreviations: n = number of twin pairs which completed the test OR – Odds Ratio CI – Confidence Interval SD – Standard Deviation RSV – Respiratory Syncytial Virus MZ – Monozygotic FEV 1 - Forced Expiratory Volume at first second PD20 – Dose of methacholine producing a 20 percent fall in FEV 1 sRaw – Specific Airway Resistance F E NO - Fractional Exhaled Nitric Oxide a Fisher’s exact test b Paired t-test c Wilcoxon's test (paired) 21
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Lung function measurements in child
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Contents Acknowledgements .........
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Acknowledgements The thesis was wri
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Introduction Symptoms of chronic re
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pulmonary function test obtained by
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I. Accuracy of Wholebody Plethysmog
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Methods Designs Study I: Six center
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"Loops" on the screen showed the re
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We included age in the analysis of
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Normative data (study I) Mean sRaw
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Additional results sRaw measurement
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After correcting the factory settin
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Normative data In the second part o
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II. -III. Lung function measurement
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of a diagnosis of asthma: Frequent
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Figure 8: Familial predisposition t
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Total twins 12.349 twin pairs Born
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Methods Designs Study II: Hospital
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Children less than 7 years were tes
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Ethics The two studies were approve
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FEV 0.5 (ml) Table 4: Baseline char
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lung symptoms, 19% said it was the
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symptoms in response to verified RS
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epigenetic factors. Acute environme
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detection changes in lung function
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that small airways were not the dis
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onciolitis. There is an increasing
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further studies are needed to inves
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Summary The Ph.D. thesis is based o
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Danish summary (Dansk resumé) Denn
Page 62 and 63: References Reference List (1) Lum S
Page 64 and 65: (25) Aurora P, Gustafsson P, Bush A
Page 66 and 67: (50) Klug B, Bisgaard H. Repeatabil
Page 68 and 69: (76) Meissner HC. Economic impact o
Page 70 and 71: (101) Young S, Arnott J, O'Keeffe P
Page 72 and 73: (125) Bisgaard H, Hermansen MN, Lol
Page 74 and 75: (151) Walton RP, Johnston SL. Role
Page 76 and 77: disease in otherwise healthy infant
Page 78 and 79: changes in asthma control. Am J Res
Page 81: Paper I
Page 84 and 85: CHEST Original Research Accuracy of
Page 86 and 87: Figure 1. Center agreement study: l
Page 88 and 89: observer as well as a common observ
Page 90 and 91: sRaw (kPa*s) Figure 1 Online: Cente
Page 93 and 94: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Page 95 and 96: 54 55 56 57 INTRODUCTION Respirator
Page 97 and 98: 97 98 99 100 Lung function test Chi
Page 99 and 100: 141 142 143 144 Mean gestational ag
Page 101 and 102: 186 187 188 189 190 The discordant
Page 103 and 104: 232 233 234 235 236 237 viruses and
Page 105 and 106: 278 ACKNOWLEDGMENTS 279 280 281 282
Page 107 and 108: 335 336 (21) Bisgaard H, Nielsen KG
Page 109 and 110: 394 395 396 (42) Wu P, Dupont WD, G
Page 111: 455 456 457 (64) Bisgaard H, Herman
Page 115: Paper III
Page 118 and 119: Abstract Background: Two-three perc
Page 120 and 121: RA 08 TSM 133; Respiratory Care Cen
Page 122 and 123: prospectively if baseline lung func
Page 124 and 125: who do not develop RSV bronchioliti
Page 126 and 127: Acknowledgements We thank all the c
Page 128 and 129: (24) ATS/ERS statement: raised volu
Page 130 and 131: (53) Stein RT, Sherrill D, Morgan W
Page 132 and 133: Figure 1: Flow chart COPSAC cohort
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Lung function measurements in children - copsac

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