Lung function measurements in children - copsac

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425 426 (53) Walton RP, Johnston SL. Role of respiratory viral infections in the development of atopic conditions. Curr Opin Allergy Clin Immunol 2008 Apr;8(2):150-3. 427 428 429 (54) Forton JT, Rowlands K, Rockett K, Hanchard N, Herbert M, Kwiatkowski DP, et al. Genetic association study for RSV bronchiolitis in infancy at the 5q31 cytokine cluster. Thorax 2009 Apr;64(4):345-52. 430 431 432 (55) Hoebee B, Rietveld E, Bont L, Oosten M, Hodemaekers HM, Nagelkerke NJ, et al. Association of severe respiratory syncytial virus bronchiolitis with interleukin-4 and interleukin-4 receptor alpha polymorphisms. J Infect Dis 2003 Jan 1;187(1):2-11. 433 434 435 (56) Choi EH, Lee HJ, Yoo T, Chanock SJ. A common haplotype of interleukin-4 gene IL4 is associated with severe respiratory syncytial virus disease in Korean children. J Infect Dis 2002 Nov 1;186(9):1207-11. 436 437 438 (57) Ermers MJ, Hoebee B, Hodemaekers HM, Kimman TG, Kimpen JL, Bont L. IL-13 genetic polymorphism identifies children with late wheezing after respiratory syncytial virus infection. J Allergy Clin Immunol 2007 May;119(5):1086-91. 439 440 (58) Rosenwasser LJ. Genetics of atopy and asthma: promoter-based candidate gene studies for IL-4. Int Arch Allergy Immunol 1997 May;113(1-3):61-4. 441 442 443 (59) van der Pouw Kraan TC, van VA, Boeije LC, van Tuyl SA, de Groot ER, Stapel SO, et al. An IL-13 promoter polymorphism associated with increased risk of allergic asthma. Genes Immun 1999 Sep;1(1):61-5. 444 445 446 447 (60) Zhu S, Chan-Yeung M, Becker AB, mich-Ward H, Ferguson AC, Manfreda J, et al. Polymorphisms of the IL-4, TNF-alpha, and Fcepsilon RIbeta genes and the risk of allergic disorders in at-risk infants. Am J Respir Crit Care Med 2000 May;161(5):1655-9. 448 449 (61) Poulsen P, Esteller M, Vaag A, Fraga MF. The epigenetic basis of twin discordance in age-related diseases. Pediatr Res 2007 May;61(5 Pt 2):38R-42R. 450 451 452 (62) Wong AH, Gottesman II, Petronis A. Phenotypic differences in genetically identical organisms: the epigenetic perspective. Hum Mol Genet 2005 Apr 15;14 Spec No 1:R11-R18. 453 454 (63) Singh SM, Murphy B, O'Reilly R. Epigenetic contributors to the discordance of monozygotic twins. Clin Genet 2002 Aug;62(2):97-103. 18
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Lung function measurements in child
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Contents Acknowledgements .........
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Acknowledgements The thesis was wri
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Introduction Symptoms of chronic re
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pulmonary function test obtained by
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I. Accuracy of Wholebody Plethysmog
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Methods Designs Study I: Six center
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"Loops" on the screen showed the re
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We included age in the analysis of
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Normative data (study I) Mean sRaw
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Additional results sRaw measurement
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After correcting the factory settin
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Normative data In the second part o
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II. -III. Lung function measurement
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of a diagnosis of asthma: Frequent
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Figure 8: Familial predisposition t
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Total twins 12.349 twin pairs Born
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Methods Designs Study II: Hospital
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Children less than 7 years were tes
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Ethics The two studies were approve
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FEV 0.5 (ml) Table 4: Baseline char
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lung symptoms, 19% said it was the
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symptoms in response to verified RS
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epigenetic factors. Acute environme
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detection changes in lung function
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that small airways were not the dis
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onciolitis. There is an increasing
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further studies are needed to inves
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Summary The Ph.D. thesis is based o
Page 60 and 61: Danish summary (Dansk resumé) Denn
Page 62 and 63: References Reference List (1) Lum S
Page 64 and 65: (25) Aurora P, Gustafsson P, Bush A
Page 66 and 67: (50) Klug B, Bisgaard H. Repeatabil
Page 68 and 69: (76) Meissner HC. Economic impact o
Page 70 and 71: (101) Young S, Arnott J, O'Keeffe P
Page 72 and 73: (125) Bisgaard H, Hermansen MN, Lol
Page 74 and 75: (151) Walton RP, Johnston SL. Role
Page 76 and 77: disease in otherwise healthy infant
Page 78 and 79: changes in asthma control. Am J Res
Page 81: Paper I
Page 84 and 85: CHEST Original Research Accuracy of
Page 86 and 87: Figure 1. Center agreement study: l
Page 88 and 89: observer as well as a common observ
Page 90 and 91: sRaw (kPa*s) Figure 1 Online: Cente
Page 93 and 94: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Page 95 and 96: 54 55 56 57 INTRODUCTION Respirator
Page 97 and 98: 97 98 99 100 Lung function test Chi
Page 99 and 100: 141 142 143 144 Mean gestational ag
Page 101 and 102: 186 187 188 189 190 The discordant
Page 103 and 104: 232 233 234 235 236 237 viruses and
Page 105 and 106: 278 ACKNOWLEDGMENTS 279 280 281 282
Page 107 and 108: 335 336 (21) Bisgaard H, Nielsen KG
Page 109: 394 395 396 (42) Wu P, Dupont WD, G
Page 113 and 114: 488 489 Table 1: Comparison of clin
Page 115: Paper III
Page 118 and 119: Abstract Background: Two-three perc
Page 120 and 121: RA 08 TSM 133; Respiratory Care Cen
Page 122 and 123: prospectively if baseline lung func
Page 124 and 125: who do not develop RSV bronchioliti
Page 126 and 127: Acknowledgements We thank all the c
Page 128 and 129: (24) ATS/ERS statement: raised volu
Page 130 and 131: (53) Stein RT, Sherrill D, Morgan W
Page 132 and 133: Figure 1: Flow chart COPSAC cohort
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