Reproduction in Domestic Animals - Facultad de Ciencias Veterinarias

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16 t h International Congress on Animal Reproduction 212 Poster Abstracts dehydrogenase (LDH)], spermatological and histological changes were investigated at the end of the 3 weeks comparatively with control group (n=6). It was observed there was a statistically significance in serum ALT, AST and LDH levels (P
16 t h International Congress on Animal Reproduction Poster Abstracts 213 P561 Precocious development of bulbourethral glands in male pigs exposed to di(2ethylhexyl) phthalate before puberty Ljungvall, K 1 , Veeramachaneni, KNR 2 , Magnusson, U 1 * 1Division of Reproduction, Dep Clinical Sciences, Swedish University of Agricultural Sciences, Sweden; 2 Animal Reproduction and Biotechnology Laboratory, Colorado State University, United States Phthalates are common industrial chemicals used in large volumes in, for instance, cosmetic products, in paints, and as plastic softeners. Acute toxicity is generally considered to be low, but reproductive effects have been reported in laboratory rodents. Typically these effects have been seen after exposure during development, especially during the foetal period. Data on effects in other, non-rodent, mammals is scarce and so are those regarding accessory reproductive glands. The objective of the current study was therefore to investigate the effect of di(2-ethylhexyl) phthalate (DEHP) on the bulbourethral glands in the pig. In this split-litter design experiment, male piglets were exposed orally three times weekly to 300mg/kg of DEHP or placebo between 3 and 7 weeks of age. The effects on the bulbourethral glands were examined morphologically immediately after the exposure at seven weeks of age in one sub-group, and postpuberally at nine months of age in the other. Three of the seven DEHP- treated animals in seven-week-old group had bulbourethral glands at a stage of maturation far more advanced than that of controls. While there were no obvious differences in the cellular composition between the treatment groups in nine-month-old animals, the bulbourethral glands were heavier (p
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Reproduction in Domestic Animals - Facultad de Ciencias Veterinarias

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