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Applications of IVIVC in Formulation Development - PQRI

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<strong>IVIVC</strong> Model – Water as Dissolution Medium<br />

Cumulative Percent Absorbed<br />

100<br />

80<br />

60<br />

40<br />

Slow Release<br />

<strong>Formulation</strong><br />

Medium Release<br />

<strong>Formulation</strong><br />

Fast Release<br />

<strong>Formulation</strong><br />

Slow and Fast <strong>IVIVC</strong><br />

R 2 = 0.949<br />

20<br />

0<br />

0 20 40 60 80 100<br />

Cumulative Percent Dissolved

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