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Applications of IVIVC in Formulation Development - PQRI

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Dissolution and Absorption Pr<strong>of</strong>iles – Water as<br />

Dissolution Medium<br />

Drug Dissolution<br />

Drug Absorption<br />

100<br />

100<br />

Cumulative Percent Label Claim Dissolved<br />

80<br />

60<br />

40<br />

20<br />

Slow Release<br />

Medium Release<br />

Fast Release<br />

Cumulative Relative Percent Absorbed<br />

80<br />

60<br />

40<br />

20<br />

Slow Release<br />

Medium Release<br />

Fast Release<br />

0<br />

0<br />

0 2 4 6 8 10 12 14 16<br />

0 2 4 6 8 10 12 14 16<br />

Time (Hours)<br />

Time (Hours)

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