Applications of IVIVC in Formulation Development - PQRI
Applications of IVIVC in Formulation Development - PQRI
Applications of IVIVC in Formulation Development - PQRI
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Approaches to a Level A <strong>IVIVC</strong><br />
<br />
Traditional Approach<br />
<br />
Non-traditional Approach<br />
% absorbed Vs % dissolved<br />
mg absorbed Vs mg dissolved<br />
One strength<br />
Multiple strengths<br />
Multiple formulations with different<br />
levels <strong>of</strong> rate-controll<strong>in</strong>g parameter<br />
Multiple formulations with different<br />
levels <strong>of</strong> rate-controll<strong>in</strong>g parameter<br />
Differences among formulations <strong>in</strong><br />
both % and mg released pr<strong>of</strong>iles<br />
Differences among formulations only<br />
<strong>in</strong> mg released pr<strong>of</strong>iles<br />
Po<strong>in</strong>t to po<strong>in</strong>t relationship between <strong>in</strong><br />
vitro dissolution (%) and <strong>in</strong> vivo<br />
dissolution (%)<br />
Po<strong>in</strong>t to po<strong>in</strong>t relationship between <strong>in</strong><br />
vitro dissolution (mg) and <strong>in</strong> vivo<br />
dissolution (mg)
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