Applications of IVIVC in Formulation Development - PQRI
Applications of IVIVC in Formulation Development - PQRI
Applications of IVIVC in Formulation Development - PQRI
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50 mg MR Tablet Dissolution Pr<strong>of</strong>iles <strong>in</strong><br />
Alternate Media<br />
100<br />
Cumulative Percent Label Claim Dissolved<br />
80<br />
60<br />
40<br />
20<br />
0.9% NaCl - Reference Media<br />
Water, f 2<br />
= 72<br />
0.1N HCl (pH 1.0), f 2<br />
= 60<br />
0.1N HCl / 0.2M Phosphate (Two-Stage), f 2<br />
= 66<br />
0.02M Acetate (pH 4.5), f 2<br />
= 81<br />
0.05M Phosphate (pH 6.8), f 2<br />
= 96<br />
0<br />
0 4 8 12 16 20 24<br />
Time (Hours)
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