Applications of IVIVC in Formulation Development - PQRI
Applications of IVIVC in Formulation Development - PQRI
Applications of IVIVC in Formulation Development - PQRI
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Case Study 4<br />
BCS Class III Drug<br />
Fraction absorbed approximately 80%<br />
<strong>Development</strong> <strong>of</strong> MR dosage for which no IR market<br />
product<br />
Multiple strengths developed to achieve same <strong>in</strong> vitro<br />
dissolution release pr<strong>of</strong>ile<br />
50mg – 70% HPMC<br />
75mg – 57% HPMC<br />
100mg – 50% HPMC<br />
200mg – 30% HPMC<br />
<strong>IVIVC</strong> desired to support development <strong>of</strong> other<br />
strengths
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