Applications of IVIVC in Formulation Development - PQRI
Applications of IVIVC in Formulation Development - PQRI
Applications of IVIVC in Formulation Development - PQRI
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Internal Predictability Measures <strong>of</strong> the Level A <strong>IVIVC</strong><br />
Internal Predictability<br />
Formula Obs AUC Pred AUC %PE Obs C max Pred C max %PE<br />
2x75mg 1703 1556 8.66 96.5 94.4 2.18<br />
Study 2<br />
1x150mg 1647 1559 5.35 94.4 94.1 0.32<br />
Study 2<br />
2x75mg 2248 2187 2.71 150 130 13.1<br />
Study 1<br />
1x150mg 2242 2200 1.87 149 130 12.8<br />
Study 1<br />
2x75mg 2224 2175 2.20 144 130 9.69<br />
Study 1<br />
Average % PE 4.16 Average % PE 7.61<br />
AUC units: mcg-hr/mL, C max units: mcg/mL
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