Applications of IVIVC in Formulation Development - PQRI
Applications of IVIVC in Formulation Development - PQRI
Applications of IVIVC in Formulation Development - PQRI
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In Vitro / In Vivo Relationship for 75mg and<br />
150mg <strong>Formulation</strong>s<br />
100<br />
80<br />
Study 1 75 mg US Mfg<br />
Study 1 75 mg PR Mfg<br />
Study 1 150 mg PR Mfg<br />
Study 2 75 mg US Mfg<br />
Study 2 150 mg PR Mfg<br />
<strong>IVIVC</strong> Model<br />
R 2 = 0.971<br />
Cumulative Percent Absorbed<br />
60<br />
40<br />
20<br />
0<br />
0 20 40 60 80 100<br />
Cumulative Percent Dissolved
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