Applications of IVIVC in Formulation Development - PQRI
Applications of IVIVC in Formulation Development - PQRI
Applications of IVIVC in Formulation Development - PQRI
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In vitro release and <strong>in</strong> vivo absorption<br />
pr<strong>of</strong>iles from 75 mg <strong>Formulation</strong>s<br />
Dissolution<br />
Absorption<br />
100<br />
100<br />
Cumulative Percent Label Claim Dissolved<br />
80<br />
60<br />
40<br />
20<br />
0<br />
Slow Release<br />
Medium Release<br />
Fast Release<br />
Dissolution Conditions:<br />
- USP I (baskets)<br />
- 100 rpm<br />
- 0.9L Water<br />
- 37 o C<br />
Cumulative Percent Absorbed<br />
80<br />
60<br />
40<br />
20<br />
0<br />
Slow Release<br />
Medium Release<br />
Fast Release<br />
0 2 4 6 8 10 12<br />
Time (Hours)<br />
0 4 8 12 16 20 24<br />
Time (Hours)
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