Applications of IVIVC in Formulation Development - PQRI
Applications of IVIVC in Formulation Development - PQRI
Applications of IVIVC in Formulation Development - PQRI
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% Polymer Prediction Model to Achieve Bioequivalence<br />
for Medium Dose <strong>Formulation</strong>s<br />
2.0<br />
C max<br />
Ratios BA Study<br />
1.8<br />
AUC Ratios BA Study<br />
C max<br />
Ratios BE Study<br />
AUC Ratios BE Study<br />
C max<br />
and AUC Geometric Mean Ratios<br />
1.6<br />
1.4<br />
1.2<br />
1.0<br />
Maximum GMR for C max<br />
% Polymer = 5.24<br />
0.8<br />
M<strong>in</strong>imum GMR for AUC<br />
% Polymer = 6.19<br />
0.6<br />
0 2 4 6 8<br />
% Polymer
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