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Applications of IVIVC in Formulation Development - PQRI

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Absorption Versus Dissolution Relationship for Drug From<br />

Low Dose Reformulation Candidates<br />

100<br />

80<br />

4.5% Polymer<br />

5.25% Polymer<br />

6.25%% Polymer<br />

6.5% Polymer<br />

7% Polymer<br />

8% Polymer<br />

<strong>IVIVC</strong> Model<br />

R 2 = 0.906<br />

Absorption<br />

60<br />

40<br />

20<br />

0<br />

0 20 40 60 80 100<br />

Dissolution

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