Applications of IVIVC in Formulation Development - PQRI
Applications of IVIVC in Formulation Development - PQRI
Applications of IVIVC in Formulation Development - PQRI
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Mean Dissolution and Absorption Pr<strong>of</strong>iles <strong>of</strong> Drug From<br />
Low Dose <strong>Formulation</strong> Candidates<br />
Dissolution<br />
Absorption<br />
100<br />
100<br />
Cumulative Percent Label Claim Dissolved<br />
80<br />
60<br />
40<br />
20<br />
8% Polymer<br />
5.25% Polymer<br />
4.5% Polymer<br />
6.25% Polymer<br />
6.5% Polymer<br />
7% Polymer<br />
Cumulative Relative Percent Absorbed<br />
80<br />
60<br />
40<br />
20<br />
8% Polymer<br />
5.25% Polymer<br />
4.5% Polymer<br />
6.25% Polymer<br />
6.5% Polymer<br />
7% Polymer<br />
0<br />
0<br />
0 2 4 6 8 10 12<br />
0 2 4 6 8 10 12<br />
Time (Hours)<br />
Time (Hours)
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