Applications of IVIVC in Formulation Development - PQRI
Applications of IVIVC in Formulation Development - PQRI
Applications of IVIVC in Formulation Development - PQRI
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% Polymer Prediction Model to Achieve Bioequivalence<br />
for Low Dose <strong>Formulation</strong>s<br />
2.5<br />
C max<br />
and AUC Geometric Mean Ratios<br />
2.0<br />
1.5<br />
1.0<br />
% Polymer vs C max<br />
Ratio<br />
R 2 = 0.9995<br />
% Polymer vs AUC Ratio<br />
R 2 = 0.9996<br />
Maximum GMR for C max<br />
% Polymer = 6.40<br />
M<strong>in</strong>imum GMR for AUC<br />
0.5<br />
0 2 4 6 8<br />
% Polymer<br />
% Polymer = 6.98
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