2007 - Chemical & Biomedical Engineering - University of South ...

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Dr. Ryan G. Toomey Assistant Professor rtoomey@eng.usf.edu (813) 974-1964 Education: Post-Doctoral Research, Institute for Microsystems Technology (IMTEK). University of Freiburg, Germany, 2002-2003 Ph.D in Chemical Engineering, University of Minnesota, Minneapolis, 2002 B.S. in Chemical Engineering, University of California, Berkeley, 1995 Research Interests: Polymeric Materials, Interfacial Phenomena, Molecular Recognition, Hydrogels Smart Polymer Structures for Microfluidics Our research program is to design and develop micro-scale polymeric structures that experience changes in shape and other properties when triggered by an external stimulus. These materials can significantly advance the capability of microfluidics and miniature biosensors, for they operate without complex circuitry or bulky instrumentation. For instance, Figure 1 shows a cell sheet on a smart surface. The surface can either be “turned on” or “turned off” to support or release cells. In the image, the surface has been turned off and the cell sheet, which was cultured on the surface, detaches and rolls off. Figure 2 shows E. Coli. (green) that has been sequestered and pinched off from an overhead solution using smart polymers (shown in red). These polymer patterns are currently being explored to separate bacteria from blood for sample processing in biosensors. This research is highly collaborative and is carried out in conjunction with Dr. Peter Stroot (Civil and Environmental Engineering, USF) and Dr. Jing Wang (Electrical Engineering, USF). Recent Publications: Toomey, R. and Tirrell, M. “Functional Polymer Brushes in Aqueous Media from Self-Assembled and Surface-Initiated Polymers” Annual Review of Physical Chemistry In press (2008). Vidyasagar, A., Majewski, J., and Toomey, R. “Temperature induced volume-phase transitions in surfacetethered Poly(N-isopropylacrylamide) networks” Macromolecules (2008). 41:3, p.919-924. Castellanos, A., DuPont, S., Heim, A., Matthews, G., Stroot, P., Moreno, W., Toomey, R. “Size-exclusion "capture and release” separations using surfacepatterned poly(N-isopropylacrylamide) hydrogels” Langmuir (2007). 23:11, p. 6391-6395. Alonzo, J., Huang, Z., Liu, M., Mays, J., Toomey, R., Dadmun, M., Kilbey S. “Looped Polymer Brushes Formed by Self-assembly of Poly(2-vinylpyridine)- polystyrene-poly(2-vinylpyridine) Triblock Copolymers at the Solid-fluid Interface. Kinetics of Preferential Adsorption.” Macromolecules (2006) 39:24, p.8434-8439. Figure 1. Cultured cell sheet released from a smart polymer (poly-Nisopropylacrylamide) surface. Photo taken by Ophir Ortiz. The approach is to use stimuli-responsive, polymer films that toggle the adsorption of specific targets in response to a stimulus. The stimulus could be temperature, pH, or a small analyte, which induces a change in the surface energy of the cross-linked layer. The response characteristics are built directly into the polymer structure, and therefore a separateu feedback loop is not required. Ultimately, we would like to use these materials to exploit subtle differences in the binding affinities of macromolecules and proteins for “bind and release” separations without having to resort to biological recognition. While fully natural or biological surfaces impart the highest level of specificity, they also lack stability in non-native environments. Our goal is to bring a level of recognition to responsive synthetic materials. In our current work, we addressing two main points: Figure 1. E. Coli. (green) sequestered between smart polymer monoliths (red).Photo by Samuel DuPont. 18
Dr. Michael VanAuker Assistant Professor AIChE Student Chapter Advisor vanauker@eng.usf.edu (813) 974-3186 website: http://www.eng.usf.edu/~vanauker Education: Ph.D. Chemical Engineering, University of Pittsburgh, PA, 1997 B.S. Chemical Engineering, University of Pittsburgh, PA, 1992 Research Interests: Biomedical Engineering, Biofluidics, Artificial Heart Valves, Cardiovascular Mechanics Fluid Mechanics of Degenerative Aortic Valve Disease The major focus of Dr. VanAuker’s research is understanding the role of fluid mechanics in the causes and consequences of cardiovascular disease, noninvasive imaging, and blood flow measurements that can be used for diagnosis/prognosis and for modeling the dynamics of the arterial system. In this project, Dr. VanAuker is conducting a detailed study of native aortic valve leaflet mechanics to determine localized stress effects that may be responsible for damage patterns seen in degenerative fibrocalcific aortic valve disease, which has an unpredictable pattern of onset and progression. By determining the relationship between solid properties, geometry, and mechanical loading (and resulting stress patterns) an index based on clinically measurable quantities will be sought that correlates with stress distributions. The index could then be prospectively tested in a clinical study to determine its ability to predict disease progression and damage potential. Recent Research Projects: ‣ Fluid Mechanics of Degenerative ‣ Aortic Valve Disease ‣ Cardiovascular Battlefield Injury Diagnostic and Treatment MEMS Technology Development ‣ Arthritis Therapy by Niosomes Targeted to Disease Specific Antigens Recent Publications: Rhodes, K.D, Strom, J.A, Rahman M, VanAuker, M.D. (2007) “Prediction of pressure recovery location in aortic valve stenosis :an in vitro validation study”.Journal of Heart Valve Disease. 16:489-494. VanAuker, M., Strom, J. and Lee, W.E. III. (2007) “Cardiovascular engineering: Current status, future trends, and its emergence as a discipline”. Paper presented at the 114 th Annual American Society for Engineering Education Conference, June 24 – 27, 2007. Available at: http://www.icee.usm.edu/icee/conference s/asee2007/authors/V.html Stress distributions in the aortic valve leaflets. Hood,E, Gonzalez, M., Plaas, A., Strom, J.A, VanAuker, M.D. (2007) “Immunotargeting of nonionic surfactant vesicles to inflammation”. International Journal of Pharmaceutics 339(1-2):222-30. Linask, K.K, VanAuker, M.D. (2007) “A role for the cytoskeleton in heart looping”. The Scientific World Journal 7:280-298. 19
Page 1 and 2: CHEMICAL & BIOMEDICAL ENGINEERING 2
Page 3 and 4: Announcing our Name Change Dr. Babu
Page 5 and 6: USF College of Engineering Pursuin
Page 7 and 8: Major Research Areas Advanced Mater
Page 9 and 10: Dr. Venkat R. Bhethanabotla Profess
Page 11 and 12: Dr. Richard Gilbert Professor gilbe
Page 13 and 14: Dr. Vinay K. Gupta Associate Profes
Page 15 and 16: Dr. Babu Joseph Professor and Chair
Page 17 and 18: Dr. J.A. Llewellyn Professor Emerit
Page 19: Dr. Aydin K. Sunol Professor sunol@
Page 23 and 24: Dr. John T. Wolan Associate Profess
Page 25 and 26: Gupta, Vinay Shim ,J .Y. and Gupta
Page 27 and 28: Cular, S., Sankaranarayanan, S., Bh
Page 29 and 30: Lee, W.E. III, et al., “A novel p
Page 31 and 32: Grants and Contracts Our Faculty we
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Page 35 and 36: Awards and Recognitions Faculty Dr.
Page 37 and 38: Students Graduated in 2007 Spring 2
Page 39 and 40: 2007 ChBME Industrial Advisory Boar
Page 41 and 42: Department of Chemical & Biomedical

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