2007 - Chemical & Biomedical Engineering - University of South ...

Dr. Mark Jaroszeski
Associate Professor
MARC U-Star Scholars Program Director
Jaroszeski@eng.usf.edu
(813) 974-4662
Education:
Post-doctoral Training: Department of Surgery, University of South Florida, Tampa,
FL, 1993-1996
Ph.D. Eng. Sci. University of South Florida, Tampa, FL, 1993
M.S. ChE. University of South Florida, Tampa, FL, 1990
B.S. ChE. University of South Florida, Tampa, FL, 1990
Research Interests: Drug and Gene Delivery, Electrofusion, Biomedical
Instrumentation, Electrophoresis
Pine Cone Extract as an Adjuvant to
Chemotherapy
The long-term objective of this study is to identify ways
to exploit the now proven immunostimulatory effects of
pine cone extract in conjunction with chemotherapy as
an adjuvant—a pharmacological agent that, when
added to a drug, increases or aids its effect. The active
component of this natural product has been identified
as a complex molecule with a high molecular weight.
Dr.Jaroszeski is using the extract in combination with
chemotherapy to treat established melanomas in a
murine model. A primary aim of the research is to
investigate different routes of administration and doses
that result in anti-tumor effects that exceed those
obtained by chemotherapy alone. Basic information
about the involvement of the immune system in this
process is obtained through histology and cellular
assays. The information gained throughout the study
will then be used to further optimize treatment. This
study relates to a very broad area of concern for human
health. Successful completion will provide a foundation
for improving chemotherapy in melanoma. It will also
suggest, due to the immunomodulating properties of
the active component of the extract, that the adjuvant
therapy can be applied to other forms of cancer.
Recent Research Projects:
‣ Pine Cone Extract as an Adjuvant to
Chemotherapy
‣ Cell-cell Electrofusion
‣ Microelectrodes for DNA Delivery to the Skin
‣ Novel Electrode for Targeted Electroporative
Delivery
‣ Electrochemotherapy for Treating Soft Tissue
Sarcomas
‣ Corona Charge for Delivering Agents to Cancer
Cells
‣ Predictable and Reproducible in Vivo Electrogene
Transfer
‣ VEGF/PDGF Gene Electroporation to Improve
Glucose Sensor Function
Recent Publications:
Heller, R., Heller, L., Jaroszeski, M., Lucas, M.,
Optimization of Cutaneous Electrically Mediated
Plasmid DNA Delivery Using Novel Electrode. Gene
Therapy, 2006.
Hoff, A., Jaroszeski, M., Gilbert, R., Heller, R.,
Corona Ion Generating Method and Apparatus for the
Manipulation of Molecules and Biological Cells. (US
Patent 6929949B2) 2006.
Jaroszeski, M., Gilbert, R., Heller, R., Nonpenetrating
Electroporation Device. (US Patent 6637890B2)
2005.
Khanna, P., Villagra, A., Kim, S., Seto, E.,
Jaroszeski, M., Kumar, A., Bhansali, S., Use of
Nanocrystalline for Microfluidic Lab-on-a-chip.
Diamonds and Related Materials, 2006. 15: p.2073-
2077.
Cover page of a book edited by
Drs. Jaroszeski, Gilbert and Heller
Electrofused Cells: green-stained and
red-stained cells (left and right) were
electrofused to create a hybrid cell (center).
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