Biological activity of IL 23 and IL 17
Biological activity of IL 23 and IL 17
Biological activity of IL 23 and IL 17
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The <strong>IL</strong>-<strong>17</strong> super family<br />
Pleiotropic <strong>activity</strong> <strong>of</strong> the <strong>IL</strong> <strong>17</strong>-family<br />
Major function <strong>of</strong> <strong>IL</strong>-<strong>17</strong>A/F/E<br />
Major function is chemoattractant<br />
<strong>activity</strong> through the induction <strong>of</strong><br />
cytokines <strong>and</strong> chemokines:<br />
<strong>IL</strong>-<strong>17</strong>A <strong>and</strong> <strong>IL</strong>-<strong>17</strong>F: neutrophili<br />
<strong>IL</strong>-<strong>17</strong>E : eosinophili<br />
Kawaguchi M et al., <strong>IL</strong>-<strong>17</strong> cytokine family. J Allergy Clin Immunol<br />
2004;114:1265-73<br />
<strong>IL</strong>-<strong>17</strong>A <strong>and</strong> <strong>IL</strong>-<strong>17</strong>F have role in<br />
airway hyper responsiveness <strong>and</strong><br />
other pathological changes<br />
including metaplasia <strong>and</strong> airway<br />
remodeling
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