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Biological activity of IL 23 and IL 17

Biological activity of IL 23 and IL 17

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<strong>IL</strong>-<strong>23</strong> in diseases:<br />

Pro-tumour <strong>activity</strong> <strong>of</strong> <strong>IL</strong>-<strong>23</strong><br />

Langowski, J. L. et al., <strong>IL</strong>-<strong>23</strong> promotes tumour incidence <strong>and</strong> growth. Nature, 2006. 442: 461–465.<br />

<strong>IL</strong>-<strong>17</strong>, G.CSF, granulocytes <strong>and</strong> macrophages are decreased in <strong>IL</strong>-<strong>23</strong> KO<br />

<strong>IL</strong>-12 <strong>and</strong> <strong>IL</strong>-<strong>23</strong> antagonize each other in tumour surveillance

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