Biological activity of IL 23 and IL 17
Biological activity of IL 23 and IL 17
Biological activity of IL 23 and IL 17
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<strong>IL</strong>-<strong>23</strong> in diseases:<br />
<strong>IL</strong>-<strong>23</strong> in autoimmune inflammation<br />
<strong>IL</strong>-<strong>23</strong> plays a central role in the establishment <strong>and</strong> maintenance <strong>of</strong> organ-specific<br />
inflammatory autoimmune diseases.<br />
<strong>IL</strong>-<strong>23</strong>p19 KO mice are resistant to<br />
EAE, CIA<br />
Cua, D.J., et al. 2003. Interleukin-<strong>23</strong> rather than interleukin-12 is<br />
the critical cytokine for autoimmune inflammation <strong>of</strong> the brain.<br />
Nature. 421:744–748.
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