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Biological activity of IL 23 and IL 17

Biological activity of IL 23 and IL 17

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• Komiyama, Y. Et al., <strong>IL</strong>-<strong>17</strong> plays an important role in the development <strong>of</strong> experimental autoimmune encephalomyelitis. J.<br />

Immunol. 2006. <strong>17</strong>7: 566–573.<br />

• Tartour E, et al.: Interleukin <strong>17</strong>, a T-cell-derived cytokine, promotes tumorigenicity <strong>of</strong> human cervical tumors in nude mice.<br />

Cancer Res 1999, 59:3698- 3704.<br />

• Benchetrit F, et al., Tartour E: Interleukin-<strong>17</strong> inhibits tumor cell growth by means <strong>of</strong> a T-cell- dependent mechanism. Blood<br />

2002, 99:2114-2121.<br />

• Patera AC, et al. : Interleukin <strong>17</strong> modulates the immune response to vaccinia virus infection. Virology 2002, 299:56-63.<br />

• Linden A, Adachi M: Neutrophilic airway inflammation <strong>and</strong> <strong>IL</strong>- <strong>17</strong>. Allergy 2002, 57:769-775.<br />

• Langrish, C. L. et al. <strong>IL</strong>-<strong>23</strong> drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 201,<br />

<strong>23</strong>3–-240 (2005).<br />

• Cua, D.J., et al. 2003. Interleukin-<strong>23</strong> rather than interleukin-12 is the critical cytokine for autoimmune inflammation <strong>of</strong> the<br />

brain. Nature. 421:744–748.<br />

• Murphy, C.A., et al. 2003. Divergent pro- <strong>and</strong> antiinflammatory roles for <strong>IL</strong>-<strong>23</strong> <strong>and</strong> <strong>IL</strong>-12 in joint autoimmune inflammation. J.<br />

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