Biological activity of IL 23 and IL 17
Biological activity of IL 23 and IL 17
Biological activity of IL 23 and IL 17
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Conclusion<br />
Central role <strong>of</strong> <strong>IL</strong>-<strong>17</strong> <strong>and</strong> <strong>23</strong> in certain organ specific inflammatory autoimmune diseases.<br />
Inhibition <strong>of</strong> <strong>IL</strong>-<strong>17</strong> <strong>activity</strong> with anti-cytokine vaccines in mouse<br />
More extensive human studies to define the precise role <strong>of</strong> <strong>IL</strong>-<strong>17</strong><br />
<strong>IL</strong>-<strong>17</strong> have displayed both pro- <strong>and</strong> anti-tumour activities.<br />
<strong>IL</strong>-12 <strong>and</strong> <strong>IL</strong>-<strong>23</strong> antagonize each other in tumour surveillance.<br />
<strong>IL</strong>-<strong>17</strong> was shown to enhance the cytotoxic T cell response to murine haematopoietic tumours<br />
It is difficult to predict the effect that <strong>IL</strong>-<strong>17</strong> inhibition will have on the susceptibility <strong>of</strong> an individual<br />
to different types <strong>of</strong> cancer.
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