Biological activity of IL 23 and IL 17

IL-17 in tumorigenesis:
conclusion
IL-17 is pleiotropic a
cytokine with opposite
activities in the regulation
of tumor growth
increased growth in nude
mice
Inhibition of immunogenic
tumors in immunocompetent
mice by T-cell-dependent
mechanism
Other cytokines have this feature
These antagonistic activities of cytokines in the regulation of tumor growth,
which often depends on the immunogenicity of the tumor model, must be
taken into consideration when these molecules are used in trials of
immunotherapy.