Biological activity of IL 23 and IL 17
Biological activity of IL 23 and IL 17
Biological activity of IL 23 and IL 17
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<strong>IL</strong>-<strong>17</strong> synergize to other cytokines<br />
• with <strong>IL</strong>-1 <strong>and</strong> TNF-α to drive expression <strong>of</strong> numerous<br />
infiammatory effector<br />
• with IFN-γ to promote chemokine gene expression<br />
<strong>IL</strong>-<strong>17</strong> is in the midst <strong>of</strong> a complex network that amplifies<br />
inflammation<br />
<strong>IL</strong>-<strong>17</strong> play during adaptive or memory immune responses.<br />
<strong>IL</strong>-<strong>17</strong> may be to trigger innate immune responses shortly after a<br />
second encounter with antigen, when the memory response is<br />
activated but when concentrations <strong>of</strong> antigen are still too low to<br />
trigger a full-scale innate immune response.<br />
Sarah L Gaffen, Biology <strong>of</strong> recently discovered cytokines: Interleukin-<strong>17</strong> – a unique inflammatory cytokine with roles in bone biology<br />
<strong>and</strong> arthritis, Arthritis Res Ther 2004, 6:240-247
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