Guidelines on Diagnosis and Treatment of Malignant Lymphomas

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Post-Transplant Lymphoproliferative Disease Definition and Incidence A spectrum of lymphoproliferative disease (PTLD) is described in transplant recipients, including post-transplant infectious mononucleosis, benign polyclonal polymorphic B-cell hyperplasia, and monoclonal polymorphic lymphoma. Most are EBV-related. ICD – 0 Code: 9970 / 1 (Polymorphic PTLD) Management Patients with post-transplant infectious mononucleosis or benign polyclonal polymorphic B-cell hyperplasia may be treated with antiviral drugs such as acyclovir. Patients with overt lymphoma should be treated with withdrawal of immunosuppression to levels consistent with graft survival, and appropriate intensive Rituximab containing chemotherapy such as R-CHOP. Close attention is required for prevention and management of opportunistic infections in these high-risk patients. Patients should be managed in a centre where a multidisciplinary team with expertise in both NHL and management of transplant patients is available 65
Common Issues in Lymphoma Management Common Issues
Page 1 and 2:
Guidelines on Diag
Page 3 and 4:
Guidelines on Diag
Page 5 and 6:
Standards In Diagnosis of Lymphoma
Page 7 and 8:
Standards in Staging of Lymphoma An
Page 9 and 10:
Pathologic Diagnosis of Lymphoma Ge
Page 11 and 12:
Hodgkin lymphoma and its differenti
Page 13 and 14:
Potential diagnostic pitfalls for l
Page 15 and 16:
Summary of the usual Immunostaining
Page 17 and 18:
Mature B-Cell Neoplasms Mature B-Ce
Page 19 and 20:
Immunophenotype The tumour cells ex
Page 21 and 22: Lymphoplasmacytic Lymphoma Definiti
Page 23 and 24: Splenic Marginal Zone Lymphoma Defi
Page 25 and 26: Extra-nodal Marginal Zone B-Cell Ly
Page 27 and 28: Persistent / progressive disease or
Page 29 and 30: Follicular Lymphoma Definition and
Page 31 and 32: Potential Pitfalls a. Failure to di
Page 33 and 34: Mantle Cell Lymphoma Definition and
Page 35 and 36: Diffuse Large B-Cell Lymphoma Defin
Page 37 and 38: Stage 1 (bulky) and stages II - IV
Page 39 and 40: Treatment Standard chemotherapy for
Page 41 and 42: Burkitt Lymphoma/Leukaemia Definiti
Page 43 and 44: CODOX-M, (3 cycles) for low risk di
Page 45 and 46: Potential pitfalls Failure to diffe
Page 47 and 48: Precursor T Cell Neoplasms PRECURSO
Page 49 and 50: Mature T-Cell and NK-Cell Neoplasms
Page 51 and 52: Potential Pitfalls Treatment planni
Page 53 and 54: Recommended Investigations Evaluati
Page 55 and 56: Mycosis Fungoides and Sézary Syndr
Page 57 and 58: ■ ■ Lymph node biopsy if there
Page 59 and 60: Primary Cutaneous CD30-Positive T-C
Page 61 and 62: Angioimmunoblastic T-Cell Lymphoma
Page 63 and 64: Prognostic factors The IPI is of li
Page 65 and 66: Hodgkin Lymphoma (HL) Definition an
Page 67 and 68: Prognostic Factors / Index: i. Earl
Page 69 and 70: Immunodeficiency Associated Lymphop
Page 71: of cases and EBV in about 50%, but
Page 75 and 76: Tumour Lysis Syndrome Tumour Lysis
Page 77 and 78: Haematopoietic Recombinant Growth F
Page 79 and 80: Follow-Up Follow-up for patients wi
Page 81 and 82: Follow-up for patients with concern
Page 83 and 84: 77 Appendix
Page 85: Lower border: The lower of (i) 5 cm
Page 88 and 89: Glossary of Treatment Regimens Chlo
Page 90: 2nd Edition. May 2010. Supported by
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Guidelines on Diagnosis and Treatment of Malignant Lymphomas

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