Guidelines on Diagnosis and Treatment of Malignant Lymphomas

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Denileukin diftitox is not available in Ireland because of
specialised storage requirements, but is an iv preparation
resulting in an ORR of 38%
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Extracorporeal photopheresis may be effective in patients
with erythrodemic disease or Sezary syndrome..
Total skin electron beam therapy may be effective for stage IB
and stage III mycosis fungoides, but is toxic and only
available in Belfast for Irish patients.
Chemotherapy regimens in advanced stages of mycosis
fungoides generally achieve short-lived complete responses
of about 30%.
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Allogeneic non-myeloablative transplant is curative and a
recent EBMT survey reported an DFS and OS of >50%
Response Evaluation
The evaluation of response to therapy is primarily clinical.
CT evaluation is appropriate in late stage disease with
visceral involvement.
Follow Up
Early stage disease patients should be reviewed with careful
clinical examination at 6-monthly intervals.
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