Guidelines on Diagnosis and Treatment of Malignant Lymphomas
Guidelines on Diagnosis and Treatment of Malignant Lymphomas
Guidelines on Diagnosis and Treatment of Malignant Lymphomas
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Pathological diagnosis <strong>of</strong> suspected lymphoid disease<br />
Receive whole Lymph Node FRESH*<br />
Freeze Sample<br />
1-2mm<br />
Whole & "RNA Later" medium<br />
RPMI Sample<br />
1-2mm<br />
(Flow cytometry & cytogenetics)<br />
Divide Node<br />
Formalin fixati<strong>on</strong><br />
<strong>and</strong> wax embedding<br />
H&E <strong>and</strong> touch<br />
prep evaluati<strong>on</strong><br />
Touch preparati<strong>on</strong>s<br />
Air Dried - Giemsa<br />
Fixed - H&E<br />
Reactive Lymphoma Other<br />
Malignancy<br />
Large Cell<br />
Small Cell<br />
Hodgkin-like<br />
Basic IHC<br />
CD3, CD20<br />
Ki 67<br />
Kappa/Lambda<br />
Bcl-2<br />
Basic IHC<br />
CLA, CD3,<br />
CD5, CD20,<br />
CD30, CD79a,<br />
ALK-1, Ki 67<br />
Basic IHC<br />
CD3, CD5,<br />
CD10, CD19<br />
CD20, CD23<br />
CD79a, Bcl-2<br />
Ki 67, CyclinD1<br />
Kappa/Lambda<br />
Basic IHC<br />
CD3, CD15<br />
CD20, CD30<br />
EMA<br />
Basic IHC<br />
Cytokeratin<br />
S100<br />
Vimentin<br />
Further IHC<br />
TdT, MPO<br />
Further IHC<br />
CD15, CD30<br />
Further IHC<br />
CD5, CD10, CD57<br />
CD79a, ALK-1<br />
MPO, MCT<br />
* For extranodal disease receive resecti<strong>on</strong> or core biopsy fresh<br />
Issue Report using WHO Classificati<strong>on</strong><br />
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