APPLICANT - Imperial College London

APPLICANT - Imperial College London APPLICANT - Imperial College London

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Post 13 – Infectious Diseases (Professor M Malim) – based at GSTT CODE: KCL/013 F1 F2 See rotation for site Guy’s and St Thomas’ NHS Foundation Trust General Surgery (Vascular) Infectious Disease (Academic Attachment) 3m Renal Medicine (St Thomas' Hospital) 3m Infectious Diseases (St Thomas’ Hospital) 4m GUM 4m Accident & Emergency 3m 4m Acute Medicine (St Thomas’ Hospital) 3m Research in the KCL Dept of Infectious Diseases spans many facets of contemporary virology, microbiology and immunology. Potential projects address questions of virus replication and gene expression, structural biology, host-pathogen interactions, adaptive and innate immunity, viral evasion from host immunity, viral evolution, the design of novel therapeutic strategies and analyses of the natural history of infections in patient cohorts. At present, a significant amount of our research is devoted to the molecular pathogenesis of HIV/AIDS, though projects in the areas of AAV (a human parvovirus), human genome engineering, and the bacteria MRSA are also available. Many of these projects are complemented by the activities of the Infectious Diseases BioBank, which is hosted by this Dept, the Infection & Immunity theme within our NIHR Biomedical Research Centre, and increasing numbers of collaborations with scientists working in the areas of genomics, structural biology and biophysics. Please refer to our website for further information, particularly on the research interests of our faculty. http://www.kcl.ac.uk/schools/medicine/research/diiid/depts/infect/infecdes.html. The associated F2 clinical attachments will be A&E and General Internal Medicine (Cardiology). Post 14 – Oncology (Professor F Nestle) – based at GSTT CODE: KCL/014 F1 F2 See rotation for site Guy’s and St Thomas’ NHS Foundation Trust General Surgery (Lower GI) (St Thomas’ Hospital) Accident & Emergency 3m 4m Trauma and Orthopaedics (St Thomas’ Hospital) General Surgery (Vascular) 3m 4m General Medicine (St Thomas’ Hospital) Medical Oncology (Academic Attachment) 3m 4m Medical Oncology (Guy’s Hospital) 3m Cancer research at KCL comprises a multidisciplinary research portfolio that maps onto and spans the entire cancer patient journey. Programmes are directed towards innovative patient care, with a presence at all stages of the iterative bench-to-bedside-to-bench cycle. This embraces patient-based molecular data collection, bioinformatics, intervention development, clinical trials and trial analysis. The Division of Cancer Studies is the fastest growing Oncology activity in the UK, with 9 Professors and a research staff numbering over 200. It is integrated with the Trusts’ clinical delivery, extending onto all three hospital sites. The Division is organised into five sections, reflecting core strengths in Breast cancer, Skin Cancer, Palliative care, Haemato-oncology, Epidemiology and Cancer molecular cell biology. These research themes are allied by cross-cutting activities and expertise in: tissue banking and analysis, proteomics, genomics, statistics, cell and tissue imaging, gene therapy, cancer stem cells, cancer immunology, metastatic disease, tumour microenvironment, signal transduction, cell cycle and transcription, genetics, functional imaging and psycho-social oncology. www.stfs.org.uk/student/academic-programmes Email: tfsacademicrecruitment@stfs.org.uk Page 51 of 70 Updated: 27 May 2010

Post 15 – Rheumatology (Professor A Smith/Professor A Cope) – based at GSTT CODE: KCL/015 F1 F2 St Thomas’ Hospital Guy’s and St Thomas’ NHS Foundation Trust General Surgery (Lower GI) General Medicine 3m Orthopaedics 3m General Medicine 4m Rheumatology 4m Accident & (Academic Emergency Attachment) 3m 4m Rheumatology 3m The F2 Trainee will be based in the Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation (CMCBI), at the London Bridge Guy’s Campus. The Academic Department of Rheumatology has an established research programme in the immunopathogenesis and immunotherapy of chronic inflammatory arthropathies, especially rheumatoid arthritis. The CMCBI laboratory at the Guy’s campus is a well equipped immunology and inflammation research facility. The trainee will be supervised by the Arthritis Research UK Professor of Rheumatology and his staff on immunological techniques and translational research in the context of rheumatic diseases. The trainee will attend research, immunology and rheumatology seminars, and have opportunities to present their research at lab meetings. Post 16 – Surgery (Mr M Waltham) – based at GSTT CODE: KCL/016 F1 F2 See rotation for site Guy’s and St Thomas’ NHS Foundation Trust General Surgery (Upper GI) (St Thomas’ Hospital) General Surgery (Vascular) 3m 4m Orthopaedics (Guy’s Hospital) Surgery (Academic Attachment) 3m 4m Elderly Care (St Thomas’ Hospital) Accident & Emergency 3m 4m General Medicine (St Thomas’ Hospital) 3m Academic Foundation doctors can come and work with existing projects on the genetics of aneurysms, imaging of carotid disease, monocytes in venous thrombosis, hypoxia as a driver for stem cell recruitment to venus thrombii. We also have projects on unstable plaque and a number of other imaging projects. Previous candidates have looked at clinical problems with assessing outcomes of surgical research, trying to find indicators for venous ulcers that will heal. There are a number of other clinical projects that are available. The associated F2 clinical attachments will be General Surgery (Vascular) and A&E. Post 17 – Pharmacology/Cardiovascular (Professor M Marber) – based at GSTT CODE: KCL/017 F1 F2 See rotation for site Guy’s and St Thomas’ NHS Foundation Trust General Surgery (Vasc) (St Thomas’ Hospital) Accident & Emergency 3m 4m Orthopaedics (Guy’s Hospital) General Medicine 3m 4m Elderly Care (St Thomas’ Hospital) Pharmacology (Academic Attachment) 3m 4m General Medicine (St Thomas’ Hospital) 3m Many critical cellular processes that determine myocardial viability and function are regulated through intracellular signalling pathways that respond to environmental or mechanical stimuli and lead to chemical modification of downstream targets. The focus of our work is on the signalling pathways that determine myocardial viability and function within www.stfs.org.uk/student/academic-programmes Email: tfsacademicrecruitment@stfs.org.uk Page 52 of 70 Updated: 27 May 2010

Post 13 – Infectious Diseases (Professor M Malim) – based at GSTT<br />

CODE: KCL/013<br />

F1<br />

F2<br />

See rotation<br />

for site<br />

Guy’s and<br />

St Thomas’<br />

NHS<br />

Foundation<br />

Trust<br />

General Surgery<br />

(Vascular)<br />

Infectious<br />

Disease<br />

(Academic<br />

Attachment)<br />

3m<br />

Renal<br />

Medicine<br />

(St Thomas'<br />

Hospital)<br />

3m<br />

Infectious<br />

Diseases<br />

(St Thomas’<br />

Hospital)<br />

4m GUM 4m Accident &<br />

Emergency<br />

3m<br />

4m<br />

Acute<br />

Medicine<br />

(St<br />

Thomas’<br />

Hospital)<br />

3m<br />

Research in the KCL Dept of Infectious Diseases spans many facets of contemporary<br />

virology, microbiology and immunology. Potential projects address questions of virus<br />

replication and gene expression, structural biology, host-pathogen interactions, adaptive and<br />

innate immunity, viral evasion from host immunity, viral evolution, the design of novel<br />

therapeutic strategies and analyses of the natural history of infections in patient cohorts. At<br />

present, a significant amount of our research is devoted to the molecular pathogenesis of<br />

HIV/AIDS, though projects in the areas of AAV (a human parvovirus), human genome<br />

engineering, and the bacteria MRSA are also available. Many of these projects are<br />

complemented by the activities of the Infectious Diseases BioBank, which is hosted by this<br />

Dept, the Infection & Immunity theme within our NIHR Biomedical Research Centre, and<br />

increasing numbers of collaborations with scientists working in the areas of genomics,<br />

structural biology and biophysics. Please refer to our website for further information,<br />

particularly on the research interests of our faculty.<br />

http://www.kcl.ac.uk/schools/medicine/research/diiid/depts/infect/infecdes.html. The<br />

associated F2 clinical attachments will be A&E and General Internal Medicine (Cardiology).<br />

Post 14 – Oncology (Professor F Nestle) – based at GSTT<br />

CODE: KCL/014<br />

F1<br />

F2<br />

See rotation<br />

for site<br />

Guy’s and<br />

St Thomas’<br />

NHS<br />

Foundation<br />

Trust<br />

General Surgery<br />

(Lower GI) (St<br />

Thomas’<br />

Hospital)<br />

Accident &<br />

Emergency<br />

3m<br />

4m<br />

Trauma and<br />

Orthopaedics<br />

(St Thomas’<br />

Hospital)<br />

General<br />

Surgery<br />

(Vascular)<br />

3m<br />

4m<br />

General<br />

Medicine<br />

(St Thomas’<br />

Hospital)<br />

Medical<br />

Oncology<br />

(Academic<br />

Attachment)<br />

3m<br />

4m<br />

Medical<br />

Oncology<br />

(Guy’s<br />

Hospital)<br />

3m<br />

Cancer research at KCL comprises a multidisciplinary research portfolio that maps onto and<br />

spans the entire cancer patient journey. Programmes are directed towards innovative patient<br />

care, with a presence at all stages of the iterative bench-to-bedside-to-bench cycle. This<br />

embraces patient-based molecular data collection, bioinformatics, intervention development,<br />

clinical trials and trial analysis. The Division of Cancer Studies is the fastest growing<br />

Oncology activity in the UK, with 9 Professors and a research staff numbering over 200. It is<br />

integrated with the Trusts’ clinical delivery, extending onto all three hospital sites. The<br />

Division is organised into five sections, reflecting core strengths in Breast cancer, Skin<br />

Cancer, Palliative care, Haemato-oncology, Epidemiology and Cancer molecular cell<br />

biology. These research themes are allied by cross-cutting activities and expertise in: tissue<br />

banking and analysis, proteomics, genomics, statistics, cell and tissue imaging, gene<br />

therapy, cancer stem cells, cancer immunology, metastatic disease, tumour<br />

microenvironment, signal transduction, cell cycle and transcription, genetics, functional<br />

imaging and psycho-social oncology.<br />

www.stfs.org.uk/student/academic-programmes<br />

Email: tfsacademicrecruitment@stfs.org.uk<br />

Page 51 of 70<br />

Updated: 27 May 2010

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