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3. POSTS Post 1 – Stroke Medicine and Elderly Care – based at Royal Sussex County Hospital/BSMS CODE: BSMS/001 F1 F2 Royal Sussex County Hospital/ Princess Royal University Hospital Royal Sussex County Hospital/ Princess Royal University Hospital Medical Assessment Unit Stroke Medicine and Elderly Care 4m General Surgery 4m General Internal Medicine/Endocri nology 4m Clinical Infectious Diseases 4m General Internal Medicine 4m 4m Professor C Rajkumar is the Charles Hunnisett Foundation Chair in Elderly Care and Stroke. His research areas are around cardiovascular laboratory-based research into ageing process of arteries & epidemiology research into hypertension & ethnic differences in cardiovascular disease. The potential projects will investigate non-invasive ways of measuring cardiovascular risk factors in patients with diabetes, renal disease and stroke. These include assessment of vascular stiffness, LV function and the role of sympathetic nervous system activity using 24 hour Holter and ambulatory BP monitoring. In addition, the candidates also take part in a number of clinical trials which are conducted by the unit. The unit is part of the South East Network for Stroke Research and there are a number of clinical studies. In the past few years, candidates who have held this post have ended up publishing in internationals journals, presenting at national and international meetings and have also been successful in obtaining positions for future careers in academic medicine. In addition to the potential to participate in various projects, the candidates have an opportunity to work in a research active environment with excellent infrastructure provided by the Clinical Research Unit of the hospital and a 50-bedded stroke unit. The candidates also have the opportunity to be trained in various research techniques to run clinical trials. Training in good clinical practice guidelines, use of statistical packages including SPSS, training in the use of Endnote and other research packages are also part of the process. Post 2 – Haematology - based in the Medical Research Building at Brighton & Sussex Medical School CODE: BSMS/002 F1 F2 Royal Sussex County Hospital/ Princess Royal University Hospital Royal Sussex County Hospital/ Princess Royal University Hospital Medical Assessment Unit General Internal Medicine 4m General Surgery 4m General Internal Medicine 4m Haematology 4m Clinical Infectious Diseases 4m 4m Haematology research at BSMS is overseen by Dr Timothy Chevassut, senior lecturer and director for academic training, who runs an active translational research programme. The research focuses primarily on understanding the biology of leukaemia and myeloma with a view exploring new therapeutic strategies in these diseases. We are particularly interested in characterising the leukaemia stem cell and identifying novel ways of targeting this to improve treatment outcomes in AML. Our laboratory is based at the Medical Research Building on the Sussex University campus at Falmer where we maintain a tissue bank of www.stfs.org.uk/student/academic-programmes Email: tfsacademicrecruitment@stfs.org.uk Page 25 of 70 Updated: 27 May 2010
patient samples. We have a number of fruitful collaborations with various other investigators working on areas to do with drug-resistance, signal transduction, genomic instability, DNA methylation and cell mitosis. Dr Chevassut also runs early phase clinical trials in AML through the Clinical Investigation Research Unit at the Royal Sussex County Hospital with five other consultant colleagues who collectively manage a busy level 2 haematology service and laboratory with in-house immunophenotyping facilities. Brighton has strong clinical and research links with King’s <strong>College</strong> Hospital and the Royal Marsden where we currently refer patients for autologous and allogeneic stem cell transplantation. Interested candidates are encouraged to look at the website for further details. http://www.bsms.ac.uk/research/oncology/tim_chevassut.htm Post 3 – Oncology– based at Royal Sussex County Hospital/BSMS CODE: BSMS/003 F1 F2 Royal Sussex County Hospital/ Princess Royal University Hospital Royal Sussex County Hospital/ Princess Royal University Hospital Medical Assessment Unit Clinical Infectious Diseases 4m General Surgery 4m General Internal Medicine/ Respiratory 4m General Internal Medicine 4m 4m Oncology 4m Both clinical and lab-based research projects are available. The Cancer in the Elderly Research Programme was developed in 2008 by Dr Alistair Ring to address the complex needs of the increasing number of older patients with cancer. Current projects are addressing such issues as fitness for cytotoxic chemotherapy, nutritional status, social support, biological markers of ageing and poly-pharmacy in older cancer patients. In addition, aspects of the epidemiology of cancer in the elderly and treatment preferences are being addressed in partnership with colleagues at the University of Sussex (Psychosocial Oncology Group) and BSMS Department of Epidemiology. The Chalmers laboratory at the Genome Damage and Stability Centre at the University of Sussex studies cellular responses to cytotoxic DNA damaging agents, with particular emphasis on glioblastoma multiforme. We are currently investigating the potential of inhibitors of DNA repair to promote tumour specific radio- and chemo-sensitisation. Previous research has led to a phase I clinical trial of the PARP inhibitor olaparib in recurrent glioblastoma multiforme. The lab offers an ideal environment for an academic F2 project to acquire experience in translational laboratory science. The candidate will be trained in cell culture techniques and a range of assays studying induction and repair of DNA damage. http://www.bsms.ac.uk/research/oncology/anthony_chalmers.htm Post 4 – Nuclear Medicine – based at Royal Sussex County Hospital/BSMS CODE: BSMS/004 F1 F2 Royal Sussex County Hospital/ Princess Royal University Hospital Royal Sussex County Hospital/ Princess Royal University Hospital General Internal Medicine 4m General Internal Medicine 4m General Surgery 4m Nuclear Medicine 4m General Practice 4m Medical Assessment Unit 4m Nuclear Medicine comprises the application of radioisotopes for the purposes of medical diagnosis and therapy. Nuclear Medicine diagnosis frequently entails the production of images which display the distribution of previously administered radioisotopes within the body. By focussing on the demonstration of disease through changes in molecular or www.stfs.org.uk/student/academic-programmes Email: tfsacademicrecruitment@stfs.org.uk Page 26 of 70 Updated: 27 May 2010
Page 1 and 2: Thames Foundation Schools Academic
Page 3 and 4: INTRODUCTION The UKFPO has publishe
Page 5 and 6: TFS Application Form Applicants for
Page 7 and 8: Applicants will be asked to indicat
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Page 11 and 12: APPENDIX A - TFS AFP PERSON SPECIFI
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Page 15 and 16: The FY2 post will give opportunitie
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Page 21 and 22: CODE: QML/014 F1 Homerton Hospital
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Page 29 and 30: eactive ferryl myoglobin. A study i
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Page 67 and 68: scleroderma and fibrosis. This is a
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