VAP prevention â non-antimicrobial methods
VAP prevention â non-antimicrobial methods
VAP prevention â non-antimicrobial methods
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Nosocomial pneumonia risk & stress ulcer prophylaxis: a<br />
comparison of pantoprazole vs. ranitidine in<br />
cardiothoracic surgery patients.<br />
Miano TA et al, Chest 2009; 136: 440-7<br />
• SUP is associated with ↑ risk of <strong>VAP</strong><br />
• PPIs are linked to ↑ risk of CAP<br />
• Retrospective review of 824 patients receiving SUP<br />
PPI<br />
N=377<br />
H 2 RA<br />
N=457<br />
Nosocomial pneumonia 9.3% 1.5% 6.6 (2.9-14.9)<br />
OR<br />
• Multivariate logistic regression – pantoprazole was only<br />
factor +ve for pneumonia: OR 2.7 (1.1-6.7)<br />
SUP unlikely to have major effect on <strong>VAP</strong>, but some effect…
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