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VAP prevention – non-antimicrobial methods

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Randomized controlled trial & meta-analysis of oral<br />

decontamination with 2% CHX for the <strong>prevention</strong> of <strong>VAP</strong>.<br />

Tantipong H et al, Infect Control Hosp Epidemiol 2008; 29: 131-6<br />

• CHX 2% applied QDS to teeth whilst intubated<br />

2% CHG<br />

N=102<br />

Control<br />

N=105<br />

P Value<br />

<strong>VAP</strong> incidence 5 12 0.08<br />

<strong>VAP</strong>/1000 vent days 7 21 0.04<br />

Irritation of oral mucosa 9.8% 0.9% 0.001<br />

• Combined results with other similar study<br />

• Relative risk for <strong>VAP</strong> 0.53 (0.31-0.9; p=0.02)<br />

Cheap intervention, 90% tolerance & its widely practiced…

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