O-Cubeâ„¢ Application Note - ThalesNano
O-Cubeâ„¢ Application Note - ThalesNano
O-Cubeâ„¢ Application Note - ThalesNano
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RESULTS OF ALKENE OZONOLYSIS<br />
Prof. Kappe’s group at University of Graz converted<br />
different alkenes to the corresponding aldehydes/ketones<br />
[3] (Scheme 1.) by reacting 0.05 M of starting materials<br />
with ozone (concentration of 5%) in the O-Cube reactor<br />
resulting in isolated yields of 72-90%, which were found to<br />
be comparable to the published batch ozonolysis results.<br />
As the two steps of the reaction process were carried<br />
out in the same reactor unit, the only process needed<br />
to obtain the 100 – 215 mg products within the 40 mins<br />
reaction time was the evaporation of solvent. Peroxide<br />
strips were used to make sure there was no ozonide and<br />
ozone remaining in the reaction mixture.<br />
RESULTS OF AMINE GROUP OZONOLYSIS<br />
Adopting the same reaction conditions from the alkene<br />
ozonolysis, an alkyl amine was oxidised to the nitro form.<br />
After ozonolysis the ozonide was quenched to result in the<br />
desired 1-nitrooctane with a 73% yield (117 mg) within 40<br />
mins.<br />
RESULTS OF THIOANISOLE OZONOLYSIS<br />
Oxidation reactions of thioethers often lead to the sulfone<br />
due to the fast oxidation of sulfoxide intermediate.<br />
Under flow conditions, by altering the reactions<br />
conditions (ozone concentration and the nature of<br />
quenching agent), both the sulfoxide and sulfone could<br />
be selectively synthesized in high yield, 84 and 87%<br />
respectively, after a simple work-up procedure. With<br />
the sulfone synthesis, the only method necessary to<br />
obtain the product was the evaporation of solvent after<br />
making sure there was no ozonide and ozone remaining in<br />
the reaction solution. Further data of the two representative<br />
reactions can be found in Scheme 3.<br />
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O-Cube <strong>Application</strong> <strong>Note</strong><br />
1.) MeOH, 25 °C, 1 mL/min, 0.05 M, 3% ozone 90%<br />
2.) NaBH 4 /MeOH, 25 °C, 0.7 mL/min<br />
1.) Me 2 CO, 25 °C, 1 mL/min, 0.05 M, 3% ozone 84%<br />
2.) 5% H 2 O/Me 2 CO, 25 °C, 0.7 mL/min<br />
Scheme 1: Ozonolysis of alkene groups followed by reductive quenching<br />
1.) EtOAc, 25 °C, 1 mL/min, 0.05 M, 10% ozone (3 equ.) 73%<br />
2.) 1.5 M H 2 O 2 /CHCl 3 , 25 °C, 0.5 mL/min<br />
Scheme 2: Ozonolysis of amine groups followed by oxidative quenching<br />
1.) Ozonolysis: MeOH, 25 °C, 1 mL/min, ozone: 1 equ.<br />
Reductive quenching: 0.1 M NaBH 4 /MeOH, 25 °C, 0.7 mL/min<br />
2.) Ozonolysis: MeOH, 25 °C, 0.5 mL/min, ozone: 4 equ.<br />
Oxidative quenching: 5 M H 2 O 2 /MeOH, 10 °C, 0.5 mL/min<br />
Scheme 3: Reaction conditions and results of thioanisole ozonolysis<br />
REFERENCES<br />
[1] (a) Bailey, P. S.; Chem. Rev., 1958, 58, 925-1010; (b) Baley, P. S.; Ozonization in Organic Chemistry, Olefinic<br />
Compounds; 1978; 1; (c) Bailey, P. S.; Ozonation in Organic Chemistry, Academic: San Diego; Chem. Abstr.; 1982, 2;<br />
312-319; (d) Razumovskij, S. D.; Zaikov, G. E.; Ozone and Its reaction with Organic Compounds; Elsevier: Amsterdam; 1984<br />
[2] Pluim, H.; Dyer-Smith, P.; Exner, M.; Chimica Oggi/Chemistry Today; 2011; 29(1); 59-62<br />
[3] Irfan, M.; Glasnov, N. T.; Kappe, O. C.; Organic Letters; 2011; 13(5); 984-987<br />
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