Susceptibility Testing of Neisseria and Haemophilus ... - SWACM
Susceptibility Testing of Neisseria and Haemophilus ... - SWACM Susceptibility Testing of Neisseria and Haemophilus ... - SWACM
Haemophilus influenzae • Beta-lactamse testing (7) The result of ampicillin susceptibility tests should be used to predict the activity of amoxicillin. The majority of isolates or H. Influenzae that are resistant to ampicillin and amoxicillin produce a TEM-type beta-lactamase. In most cases, a direct beta-lactamase test can provide a rapid means of detecting resistance to ampicillin and amoxicillin. Beta-lactamase negative ampicillin resistant strains (BLNAR) of H. influenzae exist and should be considered resistant to amox/clav, amp/sulbactam, cefaclor, cefetamet, cefonicid, cefprozil, cefuroxime, loracarbef and pip/tazo despite apparent in vitro susceptibility of some BLNAR strains to these agents. CLSI M100-S21 Table 2E
Haemophilus influenzae in the United States 2001-2002 Phenotype Beta-lactamase negative ampicillin susceptible (BLNAS) Beta-lactamase positive ampicillin resistant(BLPAR) Beta-lactamase negative ampicillin resistant(BLNAR) Prevalence (n=1,434) 1019 (71.1%) 406 (28.3%) 9 (0.6%) This is the population that is missed by beta-lactamase testing. Karlowsky et al. 2001. JCM
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<strong>Haemophilus</strong> influenzae in the<br />
United States 2001-2002<br />
Phenotype<br />
Beta-lactamase negative ampicillin<br />
susceptible (BLNAS)<br />
Beta-lactamase positive ampicillin<br />
resistant(BLPAR)<br />
Beta-lactamase negative ampicillin<br />
resistant(BLNAR)<br />
Prevalence (n=1,434)<br />
1019 (71.1%)<br />
406 (28.3%)<br />
9 (0.6%)<br />
This is the population that is missed by beta-lactamase testing.<br />
Karlowsky et al. 2001. JCM
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