Diabetic Retinopathy & Medical Retina - aioseducation

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Diabetic Retinopathy and Medical Retina Free Papers DISCUSSION There are hardly any reports on the elevated levels of PEDF in the serum or vitreous of PDR cases. However this study shows unusually higher levels of PEDF in the vitreous of PDR cases along with VEGF levels that are usually reported as high. In our study vitreous PEDF were increased only in the laser treated eyes when compared to the non-laser treated eyes. Among all the cytokines examined IL-6 was significantly increased in PDR groups when compared to MH and PEDF was negatively correlated with IL-6. In conclusion the vitreal concentration of PEDF was significantly higher in PDR than in MH. Increased PEDF levels in PDR are probably altered with laser treatment. However more cases needs to be looked into to conclude on this. Evaluation of Pattern Electroretinogram in Central Serous Retinopathy Dr. J. L. Goyal, Dr. Vishram Anil Sangit, Dr. Basudev Ghosh, Dr. Gaurav Goyal Pattern electroretinogram (PERG), an important electrophysiological modality is the response of the central retina to an isoluminant stimulus, usually a reversing black and white checker board. PERG, a newer electrophysiological modality is used to assess the macular photoreceptor and ganglion cell function. Aim of the study is to pattern electroretinogram in central serous retinopathy, primarily affecting the macular function. MATERIALS AND METHODS This prospective study was conducted at the Guru Nanak eye centre, New Delhi. 20 patients with recent onset (
70th AIOC Proceedings, Cochin 2012 fundus biomicroscopy, Fluorescein angiography and OCT. Pattern ERG was performed in all 20 patients using the Arden gold foil electrode on ISCEV standardized machine. The Arden gold foil electrode was used as the active electrode with the gold surface touching the corneoscleral limbus and non polarisable Ag/AgCl electrodes were used as the ground electrode on the forehead and reference electrode (outer canthus). Stimulus: Full field monocular stimulation was given using the Checkerboard pattern on a 17 inch monitor. The central fixation spot size was 4 mm. The patient was seated at a distance of 1 meter from the monitor such that the screen occupied 12 degree of the patient’s visual field, and with a check size of 16 the visual angle subtended was 1 degree. 150 stimuli for signal averaging at a frequency of 1 pps were used. PERG consists of a negative wave N1, a positive P50 (P1) wave driven by the macular photoreceptors thus reflecting the macular function and a negative N95(N2) wave for the assessment of the retinal ganglion cell function. P50, at 50 m.sec latency, is measured from the trough of N1 to the peak of P50. N2, at 95 m.sec latency, is measured from peak of P50 to trough of N95. 884
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