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Diabetic Retinopathy and Medical Retina Free Papers Recording of Waves a) Pattern ERG (PERG): It was recorded using a reversing checkerboard pattern with the subject seated 1 metre away from the monitor in a dark room, without mydriasis. 150 stimuli for signal averaging at a frequency of 1 pulse per second was used. The amplitude and latency of P50 (positive wave at 50 m.sec) was calculated. b) Oscillatory Potentials (OPs): Peak-to trough amplitudes of the waves was summed to give an overall measure of OP amplitude. c) Photopic Negative Response (PhNR): Its amplitude is defined as the difference between the baseline and the trough of the negative wave following the b-wave. d) 30 Hz Flicker ERG: The amplitude of flicker ERG is measured from the trough to the peak. e) The implicit time of each wave was measured from stimulus onset to the peak. RESULT It was found that the amplitude of P50 wave of Pattern ERG showed significant decrease with increase in the severity of diabetic retinopathy, with an average reading of 3.98 µV ±1.10 in control group, 2.38 µV ±0.81 in diabetics without NPDR and 1.81 µV ±0.64 in diabetics with NPDR (P value
70th AIOC Proceedings, Cochin 2012 thus, early intervention can be undertaken at an appropriate time to prevent further progression of the disease, before it reaches an irreversible stage. REFERENCES 1. Klein R, Klein BEK, Moss SE. The Winconsin Epidemiological Study of Diabetic Retinopathy, III:Prevalence and risk of diabetic retinopathy when age of diagonosis is 30 or more years. Arch Ophthalmol 1984;102:527-32. 2. Liech E, gardener TW, Barber AJ. Retinal neurodegeneration:early pathology in diabetes. ClinExpOphthalmol 2000;28: 3-8 3. Barber AJ. A new view of diabetic retinopathy: a neurodegenerative disease of the eye. Prog Neuropsychopharmol Biol Psychiatry 2003;27:283-90. 4. Lopes de Faria,Russ H Costa VP. Retinal Fibre layer loss in patients with type 1 diabetes mellitus without retinopathy. Br J Ophthalmol 2002;86:725-8. 5. Nakazawa T, Takahashi H, Nishijima K. Pitavastatin prevents NMDA-induced retinal ganglion cell death by suppressing leukocyte recruitment. J Neaurochemistry 2007;100:1018-31. 6. Coupland SG: A comparison of oscillatory potential and pattern electroretinogram measures in diabetic retinopathy. Doc Ophthalmol 1987;66:207–18. 7. Chen H, Zhang M, Huang S, Wu D. The photopic negative response of flash ERG in nonproliferative diabetic retinopathy. Doc Ophthalmol 2008;117:129-35. Investigation into The Levels of VEGF, PEDF and Other Biochemical Parameters in Diabetic Retinopathy Dr. Mohammad Arif Mulla, Dr. Gopal Lingam, Dr. Angayarkanni N., Dr. Kaviarasan To determine the levels of vascular endothelial growth factor (VEGF), cytokines, pigment epithelium derived factor (PEDF), along with other biochemical parameters in the patients with diabetes, non-proliferative diabetic retinopathy (NPDR), proliferative diabetic retinopathy (PDR) and compared with age-matched controls MATERIALS AND METHODS Study Design: Patients aged between 40-65 years with type II diabetes, NPDR and PDR and Macular hole (MH) patients as control were included in this study. This study was carried out after receiving ethical approval from the institutional ethics committee. 880
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