Tumor Initiating Cells, Cell Cycle Control and Cancer Stem Cells
Tumor Initiating Cells, Cell Cycle Control and Cancer Stem Cells Tumor Initiating Cells, Cell Cycle Control and Cancer Stem Cells
Stochastic versus hierarchical models of cancer Primary tumors Transplantation Secondary tumors Stochastic: all cells have the capacity to induce tumors but the process is not efficient (e.g. most cell die after transplantation) Hierarchical: only a small fraction of tumor cells – cancer stem cells/ tumor initiating cells – is capable of inducing tumors.
Isolation of tumorigenic cells. Al-Hajj M et al. PNAS 2003;100:3983-3988 ©2003 by National Academy of Sciences
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- Page 11 and 12: Phenotypic diversity in tumors aris
- Page 13: A model depicting the hierarchical
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- Page 24 and 25: For example: The phosphatidylinosit
- Page 26 and 27: Notes: • On average: 24 gains and
- Page 28 and 29: Regulation of cell cycle progressio
- Page 30 and 31: Phosphorylation of the retinoblasto
- Page 32 and 33: Fluctuation of cyclin levels during
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- Page 36 and 37: Figure 8.23d The Biology of Cancer
- Page 38 and 39: LxCxE binding LxCxE motif Figure 8.
- Page 40 and 41: Actions of CDK inhibitors Figure 8.
- Page 42 and 43: Figure 8.15a The Biology of Cancer
- Page 44 and 45: Regulation of p27 localization AKT
- Page 46 and 47: How do p21 and p27 regulate G1 cycl
- Page 48: As D type cyclins accumulate during
- Page 51 and 52: Mouse development and cell prolifer
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Isolation of tumorigenic cells.<br />
Al-Hajj M et al. PNAS 2003;100:3983-3988<br />
©2003 by National Academy of Sciences
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