Tumor Initiating Cells, Cell Cycle Control and Cancer Stem Cells
Tumor Initiating Cells, Cell Cycle Control and Cancer Stem Cells Tumor Initiating Cells, Cell Cycle Control and Cancer Stem Cells
The Rb - E2F - Skp2 - p27 autoinduction loop The Skp2 autoinduction loop. The model shows the core components of the Skp2 autoinduction loop. Arrowheads in (A) indicate the direction of flow through the loop that results in Skp2 autoinduction and promotes progression through the restriction point. Sequential repressive effects are indicated in (B). (B) also shows the two bidirectional events within the loop. Cyclin E-cdk2 catalyzes inactivating phosphorylations of Rb while Rb Sequestration of E2F represses transcription of cyclin E. Similarly, p27 inhibits cyclin E-cdk2 activity while cyclin E-cdk2 downregulates p27 levels by catalyzing p27 phosphorylation on T187A.
Positive and negative regulation of the Skp2 autoinduction loop.
- Page 9 and 10: Isolation of tumorigenic cells. Al-
- Page 11 and 12: Phenotypic diversity in tumors aris
- Page 13: A model depicting the hierarchical
- Page 17: Implications of CSC model to chemot
- Page 20 and 21: Proto-oncogenes promote hallmarks o
- Page 22 and 23: Hallmark Tumor suppressor Function
- Page 24 and 25: For example: The phosphatidylinosit
- Page 26 and 27: Notes: • On average: 24 gains and
- Page 28 and 29: Regulation of cell cycle progressio
- Page 30 and 31: Phosphorylation of the retinoblasto
- Page 32 and 33: Fluctuation of cyclin levels during
- Page 34 and 35: Cell cycle-dependent phosphorylatio
- Page 36 and 37: Figure 8.23d The Biology of Cancer
- Page 38 and 39: LxCxE binding LxCxE motif Figure 8.
- Page 40 and 41: Actions of CDK inhibitors Figure 8.
- Page 42 and 43: Figure 8.15a The Biology of Cancer
- Page 44 and 45: Regulation of p27 localization AKT
- Page 46 and 47: How do p21 and p27 regulate G1 cycl
- Page 48: As D type cyclins accumulate during
- Page 51 and 52: Mouse development and cell prolifer
- Page 53 and 54: Molecular Analyses of G1 Phase Prog
- Page 55: cyclin E phosphorylates p27 on Thr-
The Rb - E2F - Skp2 - p27 autoinduction loop<br />
The Skp2 autoinduction loop. The model shows the core components of the Skp2 autoinduction loop.<br />
Arrowheads in (A) indicate the direction of flow through the loop that results in Skp2 autoinduction <strong>and</strong> promotes<br />
progression through the restriction point. Sequential repressive effects are indicated in (B). (B) also shows the two<br />
bidirectional events within the loop. Cyclin E-cdk2 catalyzes inactivating phosphorylations of Rb while Rb<br />
Sequestration of E2F represses transcription of cyclin E. Similarly, p27 inhibits cyclin E-cdk2 activity while<br />
cyclin E-cdk2 downregulates p27 levels by catalyzing p27 phosphorylation on T187A.
Change language