Tumor Initiating Cells, Cell Cycle Control and Cancer Stem Cells
Tumor Initiating Cells, Cell Cycle Control and Cancer Stem Cells
Tumor Initiating Cells, Cell Cycle Control and Cancer Stem Cells
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Proliferation of Cyclin D1 −/− D2 −/− D3 −/− <strong><strong>Cell</strong>s</strong> Is Resistant to p16 INK4a but not p27<br />
<strong>and</strong> Sensitive to CDK2 siRNA<br />
(over-expression of p16<br />
- no effect)<br />
>>> In the absence of D cyclins<br />
pRb is phosphorylated by<br />
Cyclin-E-CDK2
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