Tumor Initiating Cells, Cell Cycle Control and Cancer Stem Cells

More documents

Recommendations

Info

As D type cyclins accumulate during G1 they serve two functions: 1. Catalytic: Cyclin D-dependent kinases phosphorylate Rb, contributing to its inactivation. 2. Non-catalytic: - CyclinD-CDK complexes bind <strong>and</strong> sequester p21/p27 proteins, leading to free E-CDK2 activity, which further inactivates pRb.
Page 1 and 2: Tumor Initiating Cells, Cell Cycle
Page 3: Hallmarks of Cancer: The Next Gener
Page 9 and 10: Isolation of tumorigenic cells. Al-
Page 11 and 12: Phenotypic diversity in tumors aris
Page 13: A model depicting the hierarchical
Page 17: Implications of CSC model to chemot
Page 20 and 21: Proto-oncogenes promote hallmarks o
Page 22 and 23: Hallmark Tumor suppressor Function
Page 24 and 25: For example: The phosphatidylinosit
Page 26 and 27: Notes: • On average: 24 gains and
Page 28 and 29: Regulation of cell cycle progressio
Page 30 and 31: Phosphorylation of the retinoblasto
Page 32 and 33: Fluctuation of cyclin levels during
Page 34 and 35: Cell cycle-dependent phosphorylatio
Page 36 and 37: Figure 8.23d The Biology of Cancer
Page 38 and 39: LxCxE binding LxCxE motif Figure 8.
Page 40 and 41: Actions of CDK inhibitors Figure 8.
Page 42 and 43: Figure 8.15a The Biology of Cancer
Page 44 and 45: Regulation of p27 localization AKT
Page 46 and 47: How do p21 and p27 regulate G1 cycl
Page 50 and 51: Would cells lacking all D cyclins u
Page 52 and 53: Proliferation of Cyclin D1 −/−
Page 54 and 55: Positive-feedback loops and the irr
Page 56 and 57: The Rb - E2F - Skp2 - p27 autoinduc
Page 58: Summary 1. D type cyclins respond t

Tumor Initiating Cells, Cell Cycle Control and Cancer Stem Cells

Create successful ePaper yourself

Delete template?

Save as template?