Tumor Initiating Cells, Cell Cycle Control and Cancer Stem Cells

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How do p21 and p27 regulate G1 cyclins As opposed to their inhibitory effects on E-CDK2, P21 and p27 are required for D-CDK4 complex formation & activity Figure 8.17a The Biology of Cancer (© Garland Science 2007)
Figure 8.17b The Biology of Cancer (© Garland Science 2007) In addition, Cyclin E-CDK2 facilitates its own activation by phosphorylating p27 on Thr-187, inducing its degradation
Page 1 and 2: Tumor Initiating Cells, Cell Cycle
Page 3: Hallmarks of Cancer: The Next Gener
Page 9 and 10: Isolation of tumorigenic cells. Al-
Page 11 and 12: Phenotypic diversity in tumors aris
Page 13: A model depicting the hierarchical
Page 17: Implications of CSC model to chemot
Page 20 and 21: Proto-oncogenes promote hallmarks o
Page 22 and 23: Hallmark Tumor suppressor Function
Page 24 and 25: For example: The phosphatidylinosit
Page 26 and 27: Notes: • On average: 24 gains and
Page 28 and 29: Regulation of cell cycle progressio
Page 30 and 31: Phosphorylation of the retinoblasto
Page 32 and 33: Fluctuation of cyclin levels during
Page 34 and 35: Cell cycle-dependent phosphorylatio
Page 36 and 37: Figure 8.23d The Biology of Cancer
Page 38 and 39: LxCxE binding LxCxE motif Figure 8.
Page 40 and 41: Actions of CDK inhibitors Figure 8.
Page 42 and 43: Figure 8.15a The Biology of Cancer
Page 44 and 45: Regulation of p27 localization AKT
Page 48: As D type cyclins accumulate during
Page 51 and 52: Mouse development and cell prolifer
Page 53 and 54: Molecular Analyses of G1 Phase Prog
Page 55 and 56: cyclin E phosphorylates p27 on Thr-
Page 57 and 58: Positive and negative regulation of

Tumor Initiating Cells, Cell Cycle Control and Cancer Stem Cells

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