Tumor Initiating Cells, Cell Cycle Control and Cancer Stem Cells
Tumor Initiating Cells, Cell Cycle Control and Cancer Stem Cells
Tumor Initiating Cells, Cell Cycle Control and Cancer Stem Cells
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<strong>Control</strong> of cyclin levels during the cell cycle<br />
CDC2 = Cdk1 is sufficient to drive the mammalian cell cycle - CDK4/6/3/2 are not essential<br />
for cell proliferation <strong>and</strong> early embryogenesis - till midgestation)<br />
Santamar D, Barrie C, Cerqueira A, Hunt S, Tardy C, Newton K, Ceres JF, Dubus P,<br />
Malumbres M, Barbacid M.<br />
Nature. 2007 Aug 16;448(7155):811-5.<br />
Figure 8.12 The Biology of <strong>Cancer</strong> (© Garl<strong>and</strong> Science 2007)
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