Tumor Initiating Cells, Cell Cycle Control and Cancer Stem Cells
Tumor Initiating Cells, Cell Cycle Control and Cancer Stem Cells Tumor Initiating Cells, Cell Cycle Control and Cancer Stem Cells
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03.01.2015
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Cell cycle-dependent phosphorylation of pRb – new model
Control of cyclin levels during the cell cycle CDC2 = Cdk1 is sufficient to drive the mammalian cell cycle - CDK4/6/3/2 are not essential for cell proliferation and early embryogenesis - till midgestation) Santamar D, Barrie C, Cerqueira A, Hunt S, Tardy C, Newton K, Ceres JF, Dubus P, Malumbres M, Barbacid M. Nature. 2007 Aug 16;448(7155):811-5. Figure 8.12 The Biology of Cancer (© Garland Science 2007)
- Page 1 and 2: Tumor Initiating Cells, Cell Cycle
- Page 3: Hallmarks of Cancer: The Next Gener
- Page 9 and 10: Isolation of tumorigenic cells. Al-
- Page 11 and 12: Phenotypic diversity in tumors aris
- Page 13: A model depicting the hierarchical
- Page 17: Implications of CSC model to chemot
- Page 20 and 21: Proto-oncogenes promote hallmarks o
- Page 22 and 23: Hallmark Tumor suppressor Function
- Page 24 and 25: For example: The phosphatidylinosit
- Page 26 and 27: Notes: • On average: 24 gains and
- Page 28 and 29: Regulation of cell cycle progressio
- Page 30 and 31: Phosphorylation of the retinoblasto
- Page 32 and 33: Fluctuation of cyclin levels during
- Page 36 and 37: Figure 8.23d The Biology of Cancer
- Page 38 and 39: LxCxE binding LxCxE motif Figure 8.
- Page 40 and 41: Actions of CDK inhibitors Figure 8.
- Page 42 and 43: Figure 8.15a The Biology of Cancer
- Page 44 and 45: Regulation of p27 localization AKT
- Page 46 and 47: How do p21 and p27 regulate G1 cycl
- Page 48: As D type cyclins accumulate during
- Page 51 and 52: Mouse development and cell prolifer
- Page 53 and 54: Molecular Analyses of G1 Phase Prog
- Page 55 and 56: cyclin E phosphorylates p27 on Thr-
- Page 57 and 58: Positive and negative regulation of
<strong>Cell</strong> cycle-dependent phosphorylation of pRb – new model
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