Tumor Initiating Cells, Cell Cycle Control and Cancer Stem Cells
Tumor Initiating Cells, Cell Cycle Control and Cancer Stem Cells
Tumor Initiating Cells, Cell Cycle Control and Cancer Stem Cells
You also want an ePaper? Increase the reach of your titles
YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.
Notes:<br />
• On average: 24 gains <strong>and</strong> 18 losses<br />
• Most frequent - Myc amplification <strong>and</strong> Cdkn2A/B (p16ink4a <strong>and</strong> Arf)<br />
deletion.<br />
• At least 10 known tumor suppressors not identified by this analysis -<br />
Brca2, Fbxw7, Nf2, Ptch1, Smarcb1, Stk11, Sufu, Vhl, Wt1, <strong>and</strong> Wtx<br />
- Some of these are specific to cancer types (e.g. Nf2, Wt1)<br />
- Other primarily suffer arm-level deletions (e.g. Brca2)<br />
- Some TS genes undergo point mutations not deletions
Change language