Tumor Initiating Cells, Cell Cycle Control and Cancer Stem Cells
Tumor Initiating Cells, Cell Cycle Control and Cancer Stem Cells Tumor Initiating Cells, Cell Cycle Control and Cancer Stem Cells
For example: The phosphatidylinositol 3-kinase (PI3K) signaling cascade Receptor tyrosine kinase G protein couple receptor RTK, +, onc Ras, +, onc PI3K, +, onc Pten, - , TS Akt, +, onc MDM2, +, onc P53, - , TS/onc GSK3, - B-cat, +, onc Myc, +, onc CyclinD1, +, onc TSC, -, TS + -catenin myc cyclin D Courtney, K. D. et al. J Clin Oncol; 28:1075-1083 2010 Copyright © American Society of Clinical Oncology
The landscape of somatic copy-number alteration across human cancers High-resolution Affimetric analysis (250K array containing probes for 238,270 single nucleotode polymorphisms (SNPs) for somatic copy-number alterations (SCNAs) from 3,131 cancer specimens Ink4-Arf Beroukhim R., et al Nature 463, 899-905 (18 February 2010)
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- Page 28 and 29: Regulation of cell cycle progressio
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- Page 36 and 37: Figure 8.23d The Biology of Cancer
- Page 38 and 39: LxCxE binding LxCxE motif Figure 8.
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- Page 42 and 43: Figure 8.15a The Biology of Cancer
- Page 44 and 45: Regulation of p27 localization AKT
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The l<strong>and</strong>scape of somatic copy-number alteration across human cancers<br />
High-resolution Affimetric analysis (250K array containing probes for 238,270 single nucleotode polymorphisms<br />
(SNPs) for somatic copy-number alterations (SCNAs) from 3,131 cancer specimens<br />
Ink4-Arf<br />
Beroukhim R., et al Nature 463, 899-905 (18 February 2010)
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