Tumor Initiating Cells, Cell Cycle Control and Cancer Stem Cells
Tumor Initiating Cells, Cell Cycle Control and Cancer Stem Cells
Tumor Initiating Cells, Cell Cycle Control and Cancer Stem Cells
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For example: The phosphatidylinositol 3-kinase (PI3K) signaling cascade<br />
Receptor tyrosine<br />
kinase<br />
G protein<br />
couple receptor<br />
RTK, +, onc<br />
Ras, +, onc<br />
PI3K, +, onc<br />
Pten, - , TS<br />
Akt, +, onc<br />
MDM2, +, onc<br />
P53, - , TS/onc<br />
GSK3, -<br />
B-cat, +, onc<br />
Myc, +, onc<br />
CyclinD1, +, onc<br />
TSC, -, TS<br />
+<br />
-catenin<br />
myc<br />
cyclin D<br />
Courtney, K. D. et al. J Clin Oncol; 28:1075-1083 2010<br />
Copyright © American Society of Clinical Oncology
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