Tumor Initiating Cells, Cell Cycle Control and Cancer Stem Cells
Tumor Initiating Cells, Cell Cycle Control and Cancer Stem Cells Tumor Initiating Cells, Cell Cycle Control and Cancer Stem Cells
Cancer is a highly heterogeneous disease 1. Distinct oncogenic networks 2. Distinct tumor subtypes due to different cell of origin (and transforming oncogenic networks) 3. Hierarchical organization with Cancer Stem cells (CSC)/ Tumor initiating cells (TICs) capable of self-renewal and tumorigenicity at its apex, and non-TICs which were derived from TICs but have lost their tumorigenic potential forming tumor bulk 4. Clonal evolution.
Hallmarks of Cancer: The Next Generation Douglas Hanahan and Robert A. Weinberg Cell Volume 144, Issue 5, Pages 646-674 (March 2011)
- Page 1: Tumor Initiating Cells, Cell Cycle
- Page 9 and 10: Isolation of tumorigenic cells. Al-
- Page 11 and 12: Phenotypic diversity in tumors aris
- Page 13: A model depicting the hierarchical
- Page 17: Implications of CSC model to chemot
- Page 20 and 21: Proto-oncogenes promote hallmarks o
- Page 22 and 23: Hallmark Tumor suppressor Function
- Page 24 and 25: For example: The phosphatidylinosit
- Page 26 and 27: Notes: • On average: 24 gains and
- Page 28 and 29: Regulation of cell cycle progressio
- Page 30 and 31: Phosphorylation of the retinoblasto
- Page 32 and 33: Fluctuation of cyclin levels during
- Page 34 and 35: Cell cycle-dependent phosphorylatio
- Page 36 and 37: Figure 8.23d The Biology of Cancer
- Page 38 and 39: LxCxE binding LxCxE motif Figure 8.
- Page 40 and 41: Actions of CDK inhibitors Figure 8.
- Page 42 and 43: Figure 8.15a The Biology of Cancer
- Page 44 and 45: Regulation of p27 localization AKT
- Page 46 and 47: How do p21 and p27 regulate G1 cycl
- Page 48: As D type cyclins accumulate during
- Page 51 and 52: Mouse development and cell prolifer
<strong>Cancer</strong> is a highly heterogeneous disease<br />
1. Distinct oncogenic networks<br />
2. Distinct tumor subtypes due to different cell of origin<br />
(<strong>and</strong> transforming oncogenic networks)<br />
3. Hierarchical organization with <strong>Cancer</strong> <strong>Stem</strong> cells (CSC)/<br />
<strong>Tumor</strong> initiating cells (TICs) capable of self-renewal <strong>and</strong><br />
tumorigenicity at its apex, <strong>and</strong> non-TICs which were derived from<br />
TICs but have lost their tumorigenic potential forming tumor bulk<br />
4. Clonal evolution.
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