Tumor Initiating Cells, Cell Cycle Control and Cancer Stem Cells

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Can non-TICs spontaneously reverse into TICs Primary tumors Transplantation Secondary tumors Normal <strong>and</strong> neoplastic nonstem cells can spontaneously convert to a stem-like state. Chaffer CL, Brueckmann I, Scheel C, Kaestli AJ, Wiggins PA, Rodrigues LO, Brooks M, Reinhardt F, Su Y, Polyak K, Arendt LM, Kuperwasser C, Bierie B, Weinberg RA. Proc Natl Acad Sci U S A. 2011 May 10;108(19):7950-5.
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Page 1 and 2: Tumor Initiating Cells, Cell Cycle
Page 3: Hallmarks of Cancer: The Next Gener
Page 9 and 10: Isolation of tumorigenic cells. Al-
Page 11 and 12: Phenotypic diversity in tumors aris
Page 13: A model depicting the hierarchical
Page 20 and 21: Proto-oncogenes promote hallmarks o
Page 22 and 23: Hallmark Tumor suppressor Function
Page 24 and 25: For example: The phosphatidylinosit
Page 26 and 27: Notes: • On average: 24 gains and
Page 28 and 29: Regulation of cell cycle progressio
Page 30 and 31: Phosphorylation of the retinoblasto
Page 32 and 33: Fluctuation of cyclin levels during
Page 34 and 35: Cell cycle-dependent phosphorylatio
Page 36 and 37: Figure 8.23d The Biology of Cancer
Page 38 and 39: LxCxE binding LxCxE motif Figure 8.
Page 40 and 41: Actions of CDK inhibitors Figure 8.
Page 42 and 43: Figure 8.15a The Biology of Cancer
Page 44 and 45: Regulation of p27 localization AKT
Page 46 and 47: How do p21 and p27 regulate G1 cycl
Page 48: As D type cyclins accumulate during
Page 51 and 52: Mouse development and cell prolifer
Page 53 and 54: Molecular Analyses of G1 Phase Prog
Page 55 and 56: cyclin E phosphorylates p27 on Thr-
Page 57 and 58: Positive and negative regulation of

Tumor Initiating Cells, Cell Cycle Control and Cancer Stem Cells

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