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Psychiatric Diagnosis and Classification - ResearchGate

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210 PSYCHIATRIC DIAGNOSIS AND CLASSIFICATION<br />

established. Up to the present, there is, however, no such instrument,<br />

although well-established instruments, such as the SCID, have been used<br />

to evaluate the validity of new instruments.<br />

Comparisons with LEAD Longitudinal, Expert, All Data) Diagnoses<br />

The LEAD procedure was proposed by Spitzer in 1983 [101] for the assessment<br />

of the validity of diagnostic instruments. The LEAD procedure involves<br />

``longitudinal'' evaluation, i.e. not limited to a single examination,<br />

made by ``experts'', i.e. by experienced clinicians, using ``all data'', i.e. not<br />

only data obtained during the interviews with the respondent, but also data<br />

provided from other sources, such as from family members or other significant<br />

others, hospital personnel, or case records.<br />

The LEAD procedure has been used in a number of studies to assess the<br />

validity of diagnostic instruments, e.g. the DIS [105], or the validity of<br />

personality disorder diagnoses [106]. In recent studies, data used in the<br />

procedure have themselves been obtained using semi-structured interviews.<br />

Comparisons with the Consensus Best-estimate Diagnostic Procedure<br />

The best-estimate diagnostic procedure has been proposed by Leckman et al.<br />

[107]. Comprehensive information obtained from different methods personal<br />

interview, family history from family informants, <strong>and</strong> medical<br />

records), including information obtained from clinical diagnostic interviews,<br />

is assessed by two or more experts to arrive independently <strong>and</strong><br />

then by consensus at a criterion diagnosis. The procedure has been used<br />

in particular in the field of genetics [108].<br />

CONCLUSIONS<br />

Clinical assessment instruments in psychiatry differ in the diagnostic<br />

systems that they cover, in the training <strong>and</strong> expertise needed to administer<br />

them, in their costsÐtime <strong>and</strong> moneyÐ, <strong>and</strong> in the data that they yield,<br />

from screening to comprehensive diagnosis. To guide the clinician or researcher<br />

in choosing the best instrument for a given purpose or a particular<br />

study, Robins [109] has described study-specific as well as universal criteria.<br />

Study-specific criteria include the extent to which disorders of interest are<br />

covered by the instrument e.g. with regard to subtypes, age of onset or<br />

course), appropriateness to the study sample e.g. clinical setting vs. general

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