Liz Higgins - Haematology Association of Ireland
Liz Higgins - Haematology Association of Ireland
Liz Higgins - Haematology Association of Ireland
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Plerixafor: a first in class<br />
stem cell mobilising agent<br />
Structural formula <strong>of</strong> plerixafor 16<br />
Plerixafor is a first in class CXCR4 antagonist that mobilises stem<br />
cells from the bone marrow, increasing their number in peripheral<br />
blood<br />
Its mode <strong>of</strong> action is to block the chemokine receptor 4 (CXCR4, found<br />
on stems cells), preventing binding.<br />
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