ABSTRACTS - World Psychiatric Association

task. Affective Go/NoGo task revealed that euthymic bipolars displayed
fewer correct responses and more erroneous performance with
neutral target stimuli and within unpleasant emotional context. Identification
of unpleasant stimuli and dealing with neutral stimuli context
were also significantly impaired. Elevated impulsiveness scores in
the bipolar group correlated significantly with diminished identification
of pleasant stimuli and with neutral emotional context. Our findings
suggest that the emotional valence of stimulus influences cognitive
control and selective attention in euthymic bipolars compared to
healthy subjects, and that there is an interaction between trait and
state-dependent components of impulsivity in bipolar disorder.
PO1.182.
FUNCTIONING IN EUTHYMIC BIPOLAR PATIENTS:
THE INFLUENCE OF CLINICAL AND CONTEXTUAL
FACTORS
J. Sanchez-Moreno, A. Martinez-Aran, H.F. Gadelrab, M. Cabello,
C. Torrent, C.M. Bonnin, J. Valle, M. Leonardi, J.L. Ayuso-Mateos,
E. Vieta
Bipolar Disorders Program, Clinical Institute of Neuroscience.
Hospital Clinic of Barcelona, University of Barcelona, Spain;
Department of Psychiatry, Universidad Autonoma de Madrid.
Hospital Universitario de la Princesa, Madrid, Spain; “Carlo
Besta” Neurological Institute, Milan, Italy
Recent studies have suggested a low functioning even when bipolar
patients are euthymic. In this context, the International Classification
of Functioning, Disability and Health (ICF) provides the framework
to describe the individual’s functioning and allows the study of the
interaction between patient’s health status and the environmental factors
involved. This is the first time the ICF model is used to describe
functioning and disability in bipolar patients. Eighty-eight euthymic
patients with a diagnosis of bipolar disorder (ICD-10) were included.
Clinical and socio-demographic data were recorded. The outcome
variable was performance qualifier based on ICF codes, representing
problems associated with performing activities in the current environment.
To examine the importance of clinical and contextual factors,
a hierarchical multiple regression was used. The clinical variables
that significantly predicted patient functioning were the number
of episodes, number of depressive episodes, family history of psychiatric
disorders and mild subdepressive symptoms, accounting for
34.1% of the variance of functioning (F=2.14, p=0.011). Contextual
factors (environmental and personal variables), including dysfunctional
attitudes and perceived social support, accounted for 17.5% of
the variance (F=3.04, p